Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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Outline of Final Research Achievements |
Using immortalized oral epithelial cells, we have identified genes and gene networks involved in sodium fluoride-elicited cell death accompanying endoplasmic reticulum stress. In a mouse experimental model, the behavioral and reproductive effects of clothianidine, a neonicotinoid pesticide, became serious in combination with environmental stress, which may reflect our actual situation of multiple exposure. These findings obtained here will provide a basis for understanding the molecular mechanisms of combined influences by exposures to multiple environmental chemicals in mammals.
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