A study on the involvement of immune dysfunction in chronic arsenic poisoning
| Project/Area Number |
24310048
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
SUMI Daigo 徳島文理大学, 薬学部, 准教授 (30400683)
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| Co-Investigator(Renkei-kenkyūsha) |
HIMENO Seiichiro 徳島文理大学, 薬学部, 教授 (20181117)
AKAGI Masaaki 徳島文理大学, 薬学部, 教授 (90093658)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
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| Keywords | ヒ素化合物 / 免疫毒性 / ナチュラルキラー細胞 / 分子毒性 / キラー活性 / 攻撃因子 / 抑制性受容体 / 慢性ヒ素曝露 / 脾臓 / 環境衛生学 / 中毒学 / トキシコロジー / 慢性ヒ素中毒 / 人体有害物質 |
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| Outline of Final Research Achievements |
In this study, we examined immune toxicological studies showing whether chronic arsenic exposure affects infection and tumor immunity. Exposure of NK-92 cells (human NK cells) to arsenite reduced cytotoxic activity against human leukemia K562 cell. The mechanism underlying the suppression of cytotoxic activity by arsenite were down-regulation of expression of attack factors such as granzyme B, and up-regulation of inhibitory receptors such as KIR2DL3. When it was investigated using Jurkat cells (human T cell) with an increase in IL-8 and TNF-α by chemical stimuli, arsenite stimulated IL-8 production, while inhibited TNF-α production. In addition, it was measured 27 cytokines in blood samples taken from residents in arsenic contaminated areas in Bangladesh. While the number of cytokines in accordance with the state of the arsenic contamination were increased, decreasing cytokines were also detected.
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Report
(4 results)
Research Products
(23 results)
