| Project/Area Number |
24310049
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Daiichi University, College of Pharmaceutical Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOGA Nobuyuki 中村学園大学, 栄養科学部, 教授 (80136514)
ENDO Tetsuya 北海道医療大学, 薬学部, 准教授 (10133216)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Yoshihisa 徳島文理大学, 薬学部, 教授 (90161132)
OHTA Chiho 中村学園大学, 栄養科学部, 講師 (80271435)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 代謝 / 環境動態 / ヒト / 臭素化合物 / 血清 / 海藻 / クジラ / 抗酸化活性 / 内分泌かく乱性 |
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| Outline of Final Research Achievements |
Our survey on the serum concentration of OH-PBDEs in Japanese (n=60) resulted in higher concentration of naturally produced 6-OH-BDE47, which was detected at twenties times higher levels than BDE-47. The profiles of OH-PBDEs in dry seafood (Hijiki) were coincident with those in human serum. OH-PBDEs were selectively retained in serum, whereas MeO-PBDEs were present in breast milk. The in vivo and vitro metabolism study of MeO-PBDEs resulted in the O-demethylation in the liver. The antioxidant activities (MIC) of most hydroxylated compounds were higher than that of trolox standard, whereas the activities of methoxylated ones were reduced. The antibacterial activities of these halogenated biphenols were strong against Gram-positive straining, whereas the methylated ones were not. Collectively, Japanese are exposed to naturally produced OH/MeO-PBDEs via diet, of which MeO-PBDEs are demethylated to bioactive OH-PBDEs.
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