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Development of new technology using ion beam for the investigation of pathogenesis and an early diagnosis of asbestosis

Research Project

Project/Area Number 24310067
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Quantum beam science
Research InstitutionGunma University

Principal Investigator

DOBASHI Kunio  群馬大学, 保健学研究科, 教授 (00241894)

Co-Investigator(Kenkyū-buntansha) SATO Takahiro  独立行政法人日本原子力開発機構, 放射線高度利用施設部, 研究員 (10370404)
ISHIZUKA Tamotsu  福井大学, 医学部, 教授 (50302477)
SHIMIZU Yasuo  獨協医科大学, 医学部, 講師 (80396621)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords大気microPIXE / 石綿肺 / アスベスト / 肺線維症 / 特発性間質性肺炎 / 粉塵 / 元素分布 / イオンビーム / 大気マイクロPIXE / 組織内元素分布 / 職業性呼吸器疾患 / 労働災害 / 職業性粉塵暴露 / 肺組織中の元素分布 / 塵肺
Outline of Final Research Achievements

In-air microparticle-induced X-ray emission (in-air micro-PIXE) analysis is employed to assess the spatial distribution and content of small amount of element in lung biopsy specimens. We analyzed the pathogenesis of lung fibrosis induced by inhaled asbestos or dust by microPIXE. The analysis of lung tissues from mice administrated silica particle and lung fibrosis patients showed significant increase of iron level on silica particle. And the expression of markers of oxidative stress and apoptosis were co-localized with silica particles. Lung tissues from 12 lung fibrosis patients were subjected to in-air micro-PIXE analysis. Two IIP patients showed a large quantity of Si and the co-localization of Si and Fe deposition with Fas expression.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (15 results)

All 2015 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) Remarks (2 results)

  • [Journal Article] Co-localization of iron binding on silica with p62/sequestosome1 (SQSTM1) in lung granulomas of mice with acute silicosis2015

    • Author(s)
      Shimizu Y, Dobashi K, Nagase H, Ohta K, Sano T et al
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 56 Issue: 1 Pages: 74-83

    • DOI

      10.3164/jcbn.14-44

    • NAID

      130004704980

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ROCK activation in lung of idiopathic pulmonary fibrosis with oxidative stress2014

    • Author(s)
      Shimizu Y, Dobashi K, Sano T, Yamada M.
    • Journal Title

      International journal of immunopathology and pharmacology

      Volume: 27 Pages: 37-44

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proton ion-microbeam elemental analysis for inhaled particle-induced pulmonary diseases : application for diagnosis and assessment of progression.2013

    • Author(s)
      Shimizu Y, Dobashi K.
    • Journal Title

      Curr Med Chem

      Volume: 20 Issue: 6 Pages: 789-93

    • DOI

      10.2174/0929867311320060005

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] In-air microparticle induced X-ray emission analysis of inhaled particulates in thoracic lymph node in a patient with asbestos exposure2015

    • Author(s)
      Yasuhiko Koga
    • Organizer
      2015 ATS International Conference
    • Place of Presentation
      Denver, U.S.A.
    • Year and Date
      2015-05-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] The efficacy of in-air microanalysis of particles in interstitial pneumonia lung tissue2014

    • Author(s)
      古賀 康彦
    • Organizer
      第9回高崎量子応用研究シンポジウム
    • Place of Presentation
      群馬県高崎市 高崎シティーギャラリー
    • Year and Date
      2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 間質性肺炎症例におけるパラフィン切片を用いたIn-air micro PIXE解析による肺内微粒子の元素解析2014

    • Author(s)
      古賀康彦
    • Organizer
      日本職業・環境アレルギー学会
    • Place of Presentation
      福岡ソフトリサーチパーク 福岡市
    • Year and Date
      2014-06-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] The Efficacy Of Inair Microanalysis Of Particles In Interstitial Pneumonia Lung Tissue In Patients With Or Without Occupational Exposure,2014

    • Author(s)
      Yasuhiko Koga
    • Organizer
      2014 ATS International Conference
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-05-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis on Co-Localization of Si and Fe in Lung Tissue of Silica-Inhaled Mouse by In-Air Micro-PIXE,2013

    • Author(s)
      K.Dobashi
    • Organizer
      2013 ATS International Conference
    • Place of Presentation
      Philadelphia, Pennsylvania USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 特発性間質性肺炎患者における吸入粉塵の影響の量子ビームによる解析2013

    • Author(s)
      土橋邦生
    • Organizer
      第52回日本呼吸器学会学術講演会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] 大気マイクロピクシーで診断したアルミニウム肺の一例2013

    • Author(s)
      杉崎 緑、
    • Organizer
      第207回日本呼吸器学会関東地方会
    • Place of Presentation
      エーザイ株式会社 本社
    • Related Report
      2013 Annual Research Report
  • [Presentation] ミドリゾウリムシ内のEuの三次元分布測定2012

    • Author(s)
      佐藤隆博
    • Organizer
      第28回PIXEシンポジウム
    • Place of Presentation
      東京工業大学大岡山キャンパス
    • Year and Date
      2012-11-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] 二次性肺胞蛋白症の肺組織切片中の粉塵及びマクロファージ細胞内におけるin-air micro-PIXE解析2012

    • Author(s)
      清水泰生
    • Organizer
      第28回PIXEシンポジウム
    • Place of Presentation
      東京工業大学大岡山キャンパス
    • Year and Date
      2012-11-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] 特発性間質性肺炎患者における吸入粉塵の影響の量子ビームによる解析2012

    • Author(s)
      土橋邦生
    • Organizer
      第52回日本呼吸器学会
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2012-04-21
    • Related Report
      2012 Annual Research Report
  • [Remarks] 国立大学法人群馬大学大学院保健学研究科 土橋研究室

    • URL

      http://dobashi-lab.health.gunma-u.ac.jp/21.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] Micro-PIXEによる石綿肺、吸入粉塵による間質性肺炎の新診断法と病態解明への応用

    • URL

      http://dobashi-lab.health.gunma-u.ac.jp/pdf/puxe.pdf

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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