| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
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| Outline of Final Research Achievements |
To explore the molecular mechanisms of heavy-ion induced bystander effect, a system for long-term live imaging of microbeam-irradiated cell sample was developed. As a first step, I developed a software framework for developing multiple software for different experimental purpose. Using the framework, a novel cell targeting software was build, which enables integrated sample irradiation with focusing heavy-ion microbeam. This software enabled a rapid and accurate irradiation of targeted cells with focusing heavy-ion microbeam. Thereafter, I developed software libraries for long-term real-time autofocusing and automatic imaging of the target sample. Finally, these codes were integrated into the software framework to establish a long-term bystander imaging system.
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