| Project/Area Number |
24310099
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Microdevices/Nanodevices
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| Research Institution | Meiji University (2013-2014)
Tokyo Medical and Dental University (2012) |
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Principal Investigator |
KUDO Hiroyuki 明治大学, 理工学部, 准教授 (70329118)
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| Co-Investigator(Kenkyū-buntansha) |
MITSUBAYASHI Kohji 東京医科歯科大学, 生体材料工学研究所, 教授 (40307326)
ARAKAWA Takahiro 東京医科歯科大学, 生体材料工学研究所, 講師 (50409637)
KAJIWARA Riichi 明治大学, 理工学部, 准教授 (60356772)
三林 浩二 東京医科歯科大学, 生体材料工学研究所, 教授 (40307236)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2012: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | MEMS / バイオセンサ / 電気化学 / バイオマイクロシステム / 化学センサ / 酵素センサ / 生体計測 / 生体材料 / マイクロセンサ / グルコース |
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| Outline of Final Research Achievements |
In this research, a high sensitive biosensing system suitable for multi-scale and multi-analyte biomonitoring. On the basis of biosensensors formed on the soft polymers, we utilized an Os-HRP modified carbon electrode, on which lactate oxidase was immobilized, formed on the PET sheet for biomonitoring purpose. The sensing system was utilized in the monitoring of lactic acid contained in the sweat and CSF, respectively. As a result, both lactic acid was successfully monitored using our system. The level of lactic acid in the sweat after anaerobic exercise increased by 7.2 folds in comparison with that of normal situation. This indicates that the biosensor reflects the physiological situation of the human subject.
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