Basic research for early diagnosis and therapy of Alzheimer disease with nanoparticles and compounds that promotes/inhibits aggregation of amyloid beta peptide
| Project/Area Number |
24310102
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Microdevices/Nanodevices
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SK Abdullah MD (SHEIKH Abdullah Mohammad) 島根大学, 医学部, 助教 (30403447)
SHIOTA Yuri 島根大学, 医学部, 助教 (10581415)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | アルツハイマー病 / アミロイドベータ（Aβ） / フタロシアニン / lysophosphatidylcholine / 近赤外線 / 神経細胞死 / ｱﾐﾛｲﾄﾞβ(Aβ） / アポトーシス / ナノ粒子 / Lysophosphatidylcholine / メタボローム解析 / アミロイド / β蛋白 / MALDI-TOF-MS |
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| Outline of Final Research Achievements |
We have detected lysophosphatidylcholine (LPC) as a compound that promotes amyloid beta aggregation through increase of oligomerization. On the other hand, detected phthalocyanine as a nano particle that inhibits amyloid beta aggregation, which decrease hydrophobicity and beta-sheet conformational change. The compound has no toxicity to neuronal culture and rat, leading to the possibility for therapeutic application. We produced and examined the new phthalocyanine derivatives for non-invasive near infrared ray-diagnosis of Alzheimer disease (AD) because they have high affinity to amyloid beta deposited in AD brains.
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Report
(4 results)
Research Products
(34 results)
