| Budget Amount *help |
¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Outline of Final Research Achievements |
We have detected lysophosphatidylcholine (LPC) as a compound that promotes amyloid beta aggregation through increase of oligomerization. On the other hand, detected phthalocyanine as a nano particle that inhibits amyloid beta aggregation, which decrease hydrophobicity and beta-sheet conformational change. The compound has no toxicity to neuronal culture and rat, leading to the possibility for therapeutic application. We produced and examined the new phthalocyanine derivatives for non-invasive near infrared ray-diagnosis of Alzheimer disease (AD) because they have high affinity to amyloid beta deposited in AD brains.
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