Control of Bioreaction via Oligomerization and Orientation of Tumor Suppressor Protein p53 Tetramer
| Project/Area Number |
24310152
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMAGAWA Toshiaki 北海道大学, 大学院理学研究院, 准教授 (20142177)
CHUMAN Yoshiro 新潟大学, 大学院自然科学系, 准教授 (40372263)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Keywords | ペプチド / 生物活性 / 多量体化 / 配向化 / ナノマテリアル / バイオミネラリゼーション |
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| Outline of Final Research Achievements |
Oligomerization and spatial orientation is a highly effective strategy for control and extension of functions of biomaterials. In this study, we selected biomineralization as a bioreaction and the p53 tetramerization domain structure as a spatial control element. We evaluated the effect of precisely defining the spatial orientation, arrangement and valency of the biomineralization peptide on the produced nanostructures. The results clearly have demonstrated that oligomerization and spatial orientation of biomineralization peptides via the spatial control element can effectively control the formation, structures and functions of metal nanoparticles.
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Report
(4 results)
Research Products
(75 results)
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[Journal Article] Formation of Functionalized Nanowires Based on Control of Self-Assembly Using Multiple Modified Amyloid Peptides2013
Author(s)
Hiroki Sakai, Ken Watanabe, Yuya Asanomi, Yumiko Kobayashi, Yoshiro Chuman, Lihong Shi, Takuya Masuda, Thomas Wyttenbach, Michael T. Bowers, Kohei Uosaki, and Kazuyasu Sakaguchi
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Journal Title
Adv. Funct. Mater.
Volume: 23
Pages: 4881-4887
Related Report
Peer Reviewed
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