| Project/Area Number |
24310160
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TERUYA Toshiaki 琉球大学, 教育学部, 准教授 (90375428)
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| Co-Investigator(Renkei-kenkyūsha) |
OHNO Osamu 慶應義塾大学, 理工学部, 助教 (20436992)
MIYAMOTO Kenji 慶應義塾大学, 理工学部, 准教授 (60360111)
HIRATA Kunio 理化学研究所, 放射光科学総合研究センター, 技師 (20373524)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 海洋シアノバクテリア / ビセリングビアサイド / リポペプチド / 構造決定 / 全合成 / アポトーシス / 生物活性物質 / 化学合成 / 作用機構 / 結晶構造 / 腫瘍細胞増殖阻害 / トムルリン / 小胞体ストレス / クラハイン / ビセブロモアミド / 標的生体分子探索 / ビセリンビオライドA |
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| Outline of Final Research Achievements |
We could find a lot of novel bioactive substances such as biselyngbyolides A and B and kurahayne from marine cyanobacteria collected at Okinawa and Amami Islands in Kagoshima Prefecture. These compounds induced apoptosis based on their ER stress. Crystallization and structure determination of sacro-endoplasmic reticulum calcium ATPase (SERCA) complexed with biselyngbyaside and biselyngbyolide B were achieved. Biselyngbyasides bind to SERCA with unique binding mode. We achieved chemical synthesis of biselyngbyolides A and B.
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