New Principle of Microorganism Identification: Chemistry based on Small Fluorescent Molecule and Siderophore
| Project/Area Number |
24310162
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | The University of Tokushima (2013-2014)
Hokkaido University (2012) |
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Principal Investigator |
NAMBA Kosuke 徳島大学, ヘルスバイオサイエンス研究部, 教授 (50414123)
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| Co-Investigator(Kenkyū-buntansha) |
MURATA Yoshiko 公益財団法人サントリー生命科学財団, 生物有機科学研究所, 主席研究員 (60256047)
ODA Masataka 新潟大学, 大学院医歯薬系, 准教授 (00412403)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | シデロフォア / 1,3a,6a-トリアザペンタレン / 蛍光プローブ / ビブリオフェリン / エンテロバクチン / 蛍光発色団 / トリアザペンタレン / 細菌検出 / 鉄イオン取り込み / 微生物検出 |
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| Outline of Final Research Achievements |
Novel smallest fluorescent molecules were developed, and they were introduced to siderophore that is secreted by microorganism as a natural iron chelator. We succeeded to produce various compact fluorescent molecules that cover all color region from blue to red on the basis of new fluorescent chromophore 1,3a,6a-triazapentalene originally developed in our laboratory . In addition, vibrioferrin and enterobactin as the siderophore of Vibrio parahaemolyticus and salmonella respectively were efficiently synthesized. Furthermore, the introduction of various TAPs to vivrioferrin and enterobactin was also achieved. The detection and identification of specific microorganism by using TAP-siderophore are currently underway in our laboratory.
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Report
(4 results)
Research Products
(100 results)
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[Journal Article] Synthesis of yellow and red fluorescent 1,3a,6a-triazapentalenes and the theoretical investigation of their optical properties2015
Author(s)
Kosuke Namba, Ayumi Osawa, Akira Nakayama, Akane Mera, Fumi Tano, Yoshiro Chuman, Eri Sakuda, Tetsuya Taketsugu, Kazuyasu Sakaguchi, Noboru Kitamura, Keiji Tanino
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Journal Title
Chemical Science
Volume: 6
Issue: 2
Pages: 1083-1093
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] パラウアミンの全合成2015
Author(s)
竹内公平、海原由香理、難波康祐、谷野圭持
Organizer
日本化学会第95年会
Place of Presentation
日本大学（千葉県船橋市）
Year and Date
2015-03-26
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[Presentation] パラウアミンの全合成研究2013
Author(s)
竹内公平、海原由香理、難波康祐,谷野圭持
Organizer
日本化学会北海道支部2013年冬季研究発表会
Place of Presentation
北海道大学(札幌)
Year and Date
2013-01-29
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[Presentation] Synthetic Studies on Palau'amine2013
Author(s)
Kohei Takeuchi, Yukari Kaihara, Kosuke Namba and Keiji Tanino
Organizer
13th International Conference on the Chemistry of Antibiotics and other bioactive compounds, ICCA-13
Place of Presentation
FUJI-VIEW HOTEL (Yamanashi)
Related Report
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[Presentation] Enantioselective Total Synthesis of HM-32013
Author(s)
Masahiro Yoshida, Tomoyo Kasai and Kosuke Namba
Organizer
The First Asian Conference for "MONODUKURI" Strategy by Synthetic Organic Chemistry (ACMS)
Place of Presentation
Southern Beach Hotel & Resort OKINAWA (Okinawa)
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