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Understanding the neural substrates of anxiety through mind-brain-body interactions: Integrative investigations from psychology, psychiatry and psychosomatic medicine

Research Project

Project/Area Number 24330210
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Experimental psychology
Research InstitutionKeio University

Principal Investigator

Umeda Satoshi  慶應義塾大学, 文学部, 教授 (90317272)

Co-Investigator(Kenkyū-buntansha) MIMURA Masaru  慶應義塾大学, 医学部, 教授 (00190728)
MORIGUCHI Yoshiya  独立行政法人国立精神・神経医療研究センター, 精神保健研究所, 研究員 (40392477)
Co-Investigator(Renkei-kenkyūsha) TERASAWA Yuri  慶應義塾大学, 文学部, 助教 (30585790)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords不安 / 情動 / 内受容感覚 / 島皮質 / 自律神経障害 / 自律神経反応 / 脳機能画像 / 神経心理学 / 不安障害 / パニック障害 / 心身医学
Outline of Final Research Achievements

Many recent studies have investigated the mechanisms of anxiety and panic symptoms, but causal factors of them remain unresolved. To understanding the neural substrates of anxiety, we focused on the mind-brain-body interactions from integrative perspectives including psychology, psychiatry and psychosomatic medicine. A series of experimental studies using MRI and EEG showed the importance of interoception, the involvement of the insular cortex, and that the dysfunction of this mechanism was observed in autonomic disorders.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (42 results)

All 2015 2014 2013 2012 Other

All Journal Article (22 results) (of which Peer Reviewed: 22 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Presentation (17 results) (of which Int'l Joint Research: 2 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Attenuated sensitivity to the emotions of others by insular lesion.2015

    • Author(s)
      Terasawa, Y., Kurosaki, Y., Ibata, Y., Moriguchi, Y., & Umeda, S.
    • Journal Title

      Frontiers in Psychology

      Volume: 6 Pages: 1314-1314

    • DOI

      10.3389/fpsyg.2015.01314

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fear conditioning induced by interpersonal conflicts in healthy individuals.2015

    • Author(s)
      Tada, M., Uchida, H.,, Maeda, T., Konishi, M., Umeda, S., Terasawa, Y., Nakajima, S., Mimura, M., Miyazaki, T., & Takahashi, T.
    • Journal Title

      PLOS ONE

      Volume: - Issue: 5 Pages: e0125729-e0125729

    • DOI

      10.1371/journal.pone.0125729

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural brain abnormalities in postural tachycardia syndrome: A VBM-DARTEL study.2015

    • Author(s)
      Umeda, S., Harrison, N. A., Gray, M. A., Mathias, C. J., & Critchley, H. D.
    • Journal Title

      Frontiers in Neuroscience

      Volume: 9 Pages: 34-34

    • DOI

      10.3389/fnins.2015.00034

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Neurovisceral phenotypes in the expression of psychiatric symptoms.2015

    • Author(s)
      Eccles, J. A., Owens, A. P., Mathias, C. J., Umeda, S., & Critchley, H. D.
    • Journal Title

      Frontiers in Neuroscience

      Volume: 9 Pages: 4-4

    • DOI

      10.3389/fnins.2015.00004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A longitudinal functional neuroimaging study in medication-naive depression after antidepressant treatment.2015

    • Author(s)
      Tomioka H, Yamagata B, Kawasaki S, Pu S, Iwanami A, Hirano J, Nakagome K, Mimura M.
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 3 Pages: e0120828-e0120828

    • DOI

      10.1371/journal.pone.0120828

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dependence on benzodiazepines in patients with panic disorder: a cross-sectional study.2015

    • Author(s)
      Fujii K, Uchida H, Suzuki T, Mimura M.
    • Journal Title

      Psychiatry and clinical neurosciences

      Volume: 69 Issue: 2 Pages: 93-99

    • DOI

      10.1111/pcn.12203

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of the prefrontal cortex while performing a task at preferred slow pace and metronome slow pace: a functional near-infrared spectroscopy study.2014

    • Author(s)
      Shimoda K, Moriguchi Y, Tsuchiya K, Katsuyama S, Tozato F.
    • Journal Title

      Neural plasticity.

      Volume: 2014 Pages: 1-7

    • DOI

      10.1155/2014/269120

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sex differences in the neural correlates of affective experience.2014

    • Author(s)
      Moriguchi Y, Touroutoglou A, Dickerson BC, Barrett LF.
    • Journal Title

      Social cognitive and affective neuroscience.

      Volume: in press Issue: 5 Pages: 8-8

    • DOI

      10.1093/scan/nst030

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced visual artistry and high accuracy of visual numerosity representation after left prefrontal damage2014

    • Author(s)
      Keisuke Takahata, Fumie Saito, Taro Muramatsu, Makiko Yamada, Joichiro Shirahase, Hajime Tabuchi1, Tetsuya Suhara, Masaru Mimura, Motoichiro Kato
    • Journal Title

      Neuropsychologia

      Volume: 57 Pages: 28-49

    • DOI

      10.1016/j.neuropsychologia.2014.02.022

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interoceptive sensitivity predicts sensitivity to the emotions of others.2013

    • Author(s)
      Terasawa, Y., ほか3名
    • Journal Title

      Cognition and Emotion.

      Volume: (In press) Issue: 8 Pages: 1435-48

    • DOI

      10.1080/02699931.2014.888988

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neural substrates for judgment of self-agency in ambiguous situations2013

    • Author(s)
      Hirokata Fukushima, Yurie Goto, Takaki Maeda, Motoichiro Kato, and Satoshi Umeda
    • Journal Title

      PLoS One

      Volume: 8(8) Issue: 8 Pages: e72267-e72267

    • DOI

      10.1371/journal.pone.0072267

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reasoning bias for the recall of one's own beliefs in a Smarties task for adults.2013

    • Author(s)
      Maehara, Y.
    • Journal Title

      Japanese Psychological Research

      Volume: - Issue: 3 Pages: 292-301

    • DOI

      10.1111/jpr.12009

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anterior insular cortex mediates bodily sensibility and social anxiety.2013

    • Author(s)
      Terasawa Y., ほか3名
    • Journal Title

      Social Cognitive and Affective Neuroscience

      Volume: 8 Issue: 3 Pages: 259-266

    • DOI

      10.1093/scan/nss108

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroimaging studies of alexithymia: physical, affective, and social perspectives.2013

    • Author(s)
      Moriguchi Y
    • Journal Title

      Biopsychosoc Med

      Volume: 7(1) Issue: 1 Pages: 8-8

    • DOI

      10.1186/1751-0759-7-8

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced sense of agency in chronic residual schizophrenia with predominant negative symptoms.2013

    • Author(s)
      Takaki Maeda, Keisuke Takahata, Taro Muramatsu, Tsukasa Okimura, Akihiro Koreki,,Satoru Iwashita, Masaru Mimura, and Motoichiro Kato
    • Journal Title

      Psychiatry Research

      Volume: 209(3) Issue: 3 Pages: 386-392

    • DOI

      10.1016/j.psychres.2013.04.017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] How does interoceptive awareness interact with the subjective experience of emotion? An fMRI study.2013

    • Author(s)
      Terasawa Y., ほか2名
    • Journal Title

      Human Brain Mapping

      Volume: 34 Issue: 3 Pages: 598-612

    • DOI

      10.1002/hbm.21458

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sex differences in the neural correlates of affective experience2013

    • Author(s)
      Y. Moriguchi, A. Touroutoglou, B. Dickerson, C. L, Barrett, F.
    • Journal Title

      Soc Cogn Affect Neurosci

      Volume: (印刷中)(In press)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] It's not my fault: postdictive modulation of intentional binding by monetary gains and losses.2012

    • Author(s)
      Takahata, K.
    • Journal Title

      Plos One

      Volume: 7 Issue: 12 Pages: e53421-e53421

    • DOI

      10.1371/journal.pone.0053421

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced repetition blindness with angry emotional faces2012

    • Author(s)
      Yamaoka, K., Umeda S.
    • Journal Title

      Psychologia

      Volume: 55巻 Pages: 161-170

    • NAID

      130002513469

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Daily physical complaints and hippocampal function: An fMRI study of pain modulation by anxiety.2012

    • Author(s)
      Gondo M
    • Journal Title

      NeuroImage

      Volume: 63(3) Issue: 3 Pages: 1011-9

    • DOI

      10.1016/j.neuroimage.2012.07.025

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coping strategies for antidepressant side effects: An Internet survey2012

    • Author(s)
      Kikuchi T, Suzuki T, Uchida H, Watanabe K, Mimura M
    • Journal Title

      Journal of Affective Disorders

      Volume: 143巻 Issue: 1-3 Pages: 89-94

    • DOI

      10.1016/j.jad.2012.04.039

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant sense of agency in patients with schizophrenia: Forward and backward over-attribution of temporal causality during intentional action.2012

    • Author(s)
      Maeda T, Kato M, Muramatsu T, Iwashita S, Mimura M, Kashima H
    • Journal Title

      Psychiatry Research

      Volume: 198巻

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Structural brain abnormalities in postural tachycardia syndrome: A VBM-DARTEL study.2015

    • Author(s)
      Umeda, S., Harrison, N. A., Gray, M. A., Mathias, C. J., & Critchley, H. D.
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Insular lesion and attenuated sensitivity to the emotions of others2015

    • Author(s)
      Terasawa, Y., Kurosaki, Y., Ibata, Y., Moriguchi, Y., & Umeda, S.
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 内受容感覚が心拍・呼吸の変動に及ぼす影響: 心拍に近い速さの刺激を用いた検討2015

    • Author(s)
      田仲祐登・寺澤悠理・梅田聡
    • Organizer
      日本心理学会第79回大会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-09-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 視線による反射的視覚定位と表情: ERPを用いた考察2014

    • Author(s)
      辻 幸樹・梅田 聡
    • Organizer
      日本心理学会第78回大会
    • Place of Presentation
      京都・同志社大学
    • Year and Date
      2014-09-10 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 自閉症傾向から見た「心の理論」の自発性2014

    • Author(s)
      福田春奈・梅田 聡
    • Organizer
      日本心理学会第78回大会
    • Place of Presentation
      京都・同志社大学
    • Year and Date
      2014-09-10 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dissociation between interoceptive and emotional awareness in alexithymia.2014

    • Author(s)
      Terasawa, Y., Moriguchi, Y., Kanayama, Y., Oba, K., Motomura, Y., Umeda, S., & Mishima, K.
    • Organizer
      The 20th International Conference on Functional Mapping of the Human Brain.
    • Place of Presentation
      ドイツ・ハンブルク
    • Year and Date
      2014-06-08 – 2014-06-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neutral basis for autogenic training2013

    • Author(s)
      H. Murakami, R. Katsunuma, K. Oba, Y. Terasawa, Y. Motomura, Y. Kanayama, K. Mishima, Y. Moriguchi, H. Matsuda
    • Organizer
      The 71st Annual Meeting of the American Psychosomatic Society
    • Place of Presentation
      Miami, FL, USA
    • Year and Date
      2013-04-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] Neurofeedback-guided Mindfulness-based Attention Training with Real time FMRI2013

    • Author(s)
      Y. Moriguchi, K. Oba, H. Murakami, R. Katsunuma, Y. Terasawa, Y. Kanayama, A. Hida, T. Hanakawa, K. Mishima
    • Organizer
      Symposium 135: New Innovations in Neuroimaging of Autonomic Regulation in The 7 1st Annual Scientific Meeting of American Psychosomatic Society
    • Place of Presentation
      Miami, FL, USA
    • Year and Date
      2013-04-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] Application of real-time fMRI to cockroach phobia2013

    • Author(s)
      Y. Moriguchi, K. Oba, H. Murakami, R. Katsunuma, Y. Terasawa, Y. Kanayama, A. Hida, T. Hanakawa, K. Mishima
    • Organizer
      71st Annual Scientific Meeting, American Psychosomatic Society
    • Place of Presentation
      Miami, FL, USA
    • Year and Date
      2013-04-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] 主観的感情を生み出す内受容感覚の役割2013

    • Author(s)
      梅田聡
    • Organizer
      第2回社会神経科学研究会
    • Place of Presentation
      愛知、日本
    • Year and Date
      2013-01-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bodily responses and the vulnerability to anxiety: An fMRI investigation2013

    • Author(s)
      Umeda, S., Harrison, N. A., Gray, M. A., Mathias, C. J., & Critchley, H. D.
    • Organizer
      The 6th annual meeting of the Social & Affective Neuroscience Society
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Association between emotional awareness and neural correlates of interoception2013

    • Author(s)
      Terasawa, Y., Moriguchi, Y., Kanayama, Y., Oba, K., Motomura, Y., Umeda, S. & Mishima, K.
    • Organizer
      The 53th Annual Meeting of the Society for Psychophysiological Research
    • Place of Presentation
      Florence, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] 展望記憶の想起と自律神経反応2013

    • Author(s)
      栃澤彩子・梅田 聡
    • Organizer
      日本心理学会第77回大会
    • Place of Presentation
      札幌コンベンションセンター, 北海道
    • Related Report
      2013 Annual Research Report
  • [Presentation] 視線手がかり効果に及ぼす表情とアレキシサイミア傾向の影響2013

    • Author(s)
      辻 幸樹・大隅尚広・梅田 聡
    • Organizer
      日本心理学会第77回大会
    • Place of Presentation
      札幌コンベンションセンター, 北海道
    • Related Report
      2013 Annual Research Report
  • [Presentation] 社会不安と内受容感覚をつなぐ島皮質前部の活動2012

    • Author(s)
      寺澤悠理、柴田みどり、守口善也、梅田聡
    • Organizer
      日本情動学会大2回大会
    • Place of Presentation
      東京、日本
    • Year and Date
      2012-12-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] Exaggerated autonomic responses and vulnerability to anxiety2012

    • Author(s)
      Umeda, S.
    • Organizer
      The 6th Biennial Conference of the International Society for Affecitive Disorders (ISAD) Symposium
    • Place of Presentation
      London, UK
    • Year and Date
      2012-04-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] The involvement of anterior insular cortex in social anxiety and interoceptive sensibility2012

    • Author(s)
      Y. Terasawa, M. Shibata, Y. Maehara, Y. Moriguchi, S. Umeda
    • Organizer
      Cognitive Neuroscience Society 2012 Annual Meeting
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2012-04-02
    • Related Report
      2012 Annual Research Report
  • [Book] 共感2014

    • Author(s)
      梅田 聡・安西祐一郎・今井むつみ・入來篤史・片山容一・亀田達也・開 一夫・山岸俊男
    • Total Pages
      190
    • Publisher
      岩波書店
    • Related Report
      2014 Annual Research Report
  • [Remarks]

    • URL

      http://www.flet.keio.ac.jp/~umeda/article.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://pathophys.com/

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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