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Stopping power of liquids and ionization cross sections of biomolecules (amino acids, nucleobases) by energetic fast heavy ions

Research Project

Project/Area Number 24340096
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Atomic/Molecular/Quantum electronics
Research InstitutionKyoto University

Principal Investigator

Itoh Akio  京都大学, 工学(系)研究科(研究院), 教授 (90243055)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords液体分子線 / 原子衝突 / 生体分子 / アミノ酸 / 二次電子 / 飛行時間法 / 多原子分子多重分解 / 生体分子標的 / 液体標的 / 二次イオン / 電離断面積
Outline of Final Research Achievements

This project aims to provide detailed information about ionization and fragmentation of biomolecules (amino acids, nucleobases), prepared in liquid and gas phases, bombarded by MeV energy ion beams. Precise experimental data are presented for ionization cross sections by using traditional electron spectroscopy in which energy and angular distributions of secondary electrons are measured. In addition, we present a novel technique combining the time-of-flight measurements of ions and the number distribution of secondary electrons. By means of this technique multiple ionization and fragmentation of polyatomic molecules have been investigated in detail. The project has been accomplished successfully, resulting in 12 papers in the first-class international journals, 21 papers in international conferences and 34 presentations in various domestic conferences and seminars.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (30 results)

All 2016 2015 2014 2013 2012

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 3 results,  Acknowledgement Compliant: 4 results) Presentation (20 results) (of which Int'l Joint Research: 6 results,  Invited: 2 results)

  • [Journal Article] In situ X-ray diffraction study of irradiation-induced lattice expansion in Al foils by MeV-energy heavy ions2016

    • Author(s)
      Hideaki Minagawa, Hidetsugu Tsuchida, Ryu Murase, Akio Itoh
    • Journal Title

      Nuclear Instruments and Methods in Physics Research B

      Volume: 372 Pages: 38-43

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of radical scavengers on aqueous solutions exposed to heavy-ion irradiation using the liquid microjet technique2015

    • Author(s)
      S. Nomura, H. Tsuchida, R. Furuya, K. Miyahara, T.Majima, Akio Itoh
    • Journal Title

      Nuclear Instruments and Methods in Physics Research B

      Volume: 365 Pages: 611-615

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Secondary ion emission from ethanol microdroplets induced by fast heavy ions2015

    • Author(s)
      T. Majima, K. Kitajima, T. Nishio, H. Tsuchida and A. Itoh
    • Journal Title

      Journal of Physics: Conference Series

      Volume: 635 Issue: 1 Pages: 012021-012021

    • DOI

      10.1088/1742-6596/635/1/012021

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Correlation between multiple ionization and fragmentation of C_2H_6 in charge-changing collisions with 580-keV C^+2014

    • Author(s)
      T. Majima, T. Murai, T. Kishimoto, Y.Adachi, S.O.Yoshida, H. Tsuchida and A. Itoh
    • Journal Title

      Physical Review A

      Volume: 90 Issue: 6

    • DOI

      10.1103/physreva.90.062711

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Fragmentation of molecules under charge-changing collisions of a few MeV heavy ions2014

    • Author(s)
      T. Mizuno and A. Itoh
    • Journal Title

      Journal of Physics: Conference Series

      Volume: 488 Issue: 1 Pages: 12027-12027

    • DOI

      10.1088/1742-6596/488/1/012027

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ionization induced by protons on isolated molecules of adenine: theory, modelling and experiment2014

    • Author(s)
      C. Champion, M. E. Galassi, P. F. Weck, C. Abdallah, Z. Francis, M. A. Quinto, O. Foj?n, R. D. Rivarola, J. Hanssen, Y. Iriki, A. Itoh
    • Journal Title

      Journal of Physics: Conference Series

      Volume: 488 Issue: 1 Pages: 12038-12038

    • DOI

      10.1088/1742-6596/488/1/012038

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Target dependence of single-electron-capture cross sections for slow Be, C,C,Fe,Ni, and W ions2013

    • Author(s)
      M. Imai, Y. Iriki, and A. Itoh
    • Journal Title

      Fusion Science and Technology

      Volume: 63 Pages: 392-399

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Charge-state distributions of fast diatomic carbon ions and dissociated fragments passing2013

    • Author(s)
      J. Yokoe, H. Tsuchida, K. Nishimura, R. Murakoshi, S. Mori,M. Naitoh, T. Majima and A. Itoh
    • Journal Title

      J. Phys. B: At. Mol. Opt. Phys.

      Volume: 46 Issue: 11 Pages: 115201-115201

    • DOI

      10.1088/0953-4075/46/11/115201

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proton-induced ionization of isolated uracil molecules: A theory/experiment confrontation2013

    • Author(s)
      C. Champion, M.E. Galassi, P.F. Weck, S. Incerti, R.D. Rivarola, O. Fojon, J. Hanssen, Y. Iriki, A. Itoh
    • Journal Title

      Nuclear Instruments and Methods in Physics Research B

      Volume: 314 Pages: 66-70

    • DOI

      10.1016/j.nimb.2013.04.063

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross sections for ionization of uracil by MeV-energy-proton impact2013

    • Author(s)
      A. Itoh, Y. Iriki, M. Imai, C. Champion, and R. D. Rivarola
    • Journal Title

      PHYSICAL REVIEW A

      Volume: 88 Pages: 52711-52711

    • NAID

      120005357340

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Fragmentation of multiply ionized biomolecules induced by MeV heavy ions2015

    • Author(s)
      S. Yoshida, T. Majima, T. Asai, M. Matsubara, H. Tsuchida, A. Itoh
    • Organizer
      29th International Conference on Photonic, Electronic and Atomic Collisions (ICPEAC2015)
    • Place of Presentation
      トレド、スペイン
    • Year and Date
      2015-07-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Positive and negative ion emission from microdroplets by MeV energy ions2015

    • Author(s)
      T. Majima, K. Kitajima, Y. Oonishi, H. Ueda, H. Tsuchida, A. Itoh
    • Organizer
      29th International Conference on Photonic, Electronic and Atomic Collisions (ICPEAC2015)
    • Place of Presentation
      トレド、スペイン
    • Year and Date
      2015-07-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Correlation between multiple ionization and fragmentation of small hydrocarbon molecules induced by fast heavy ions2015

    • Author(s)
      T. Majima, S. Yoshida, T. Asai, M. Matsubara, H. Tsuchida, A. Itoh
    • Organizer
      29th International Conference on Photonic, Electronic and Atomic Collisions (ICPEAC2015)
    • Place of Presentation
      トレド、スペイン
    • Year and Date
      2015-07-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Coincidence measurements between multiple ionization and fragmentation of acetylene molecules induced by fast heavy ions2015

    • Author(s)
      S. Yoshida, T. Majima, T. Asai, M. Matsubara, H. Tsuchida, A. Itoh
    • Organizer
      9th International Symposium on Swift Heavy Ions in Matter (SHIM-2015)
    • Place of Presentation
      ダルムシュタット、ドイツ
    • Year and Date
      2015-05-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reversibility of heavy -ion-induced deformation of metallic foils2015

    • Author(s)
      H. Minagawa, H. Tsuchida, A. Itoh, R. Murase
    • Organizer
      9th International Symposium on Swift Heavy Ions in Matter (SHIM-2015)
    • Place of Presentation
      ダルムシュタット、ドイツ
    • Year and Date
      2015-05-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Heavy ion irradiation effects in aqueous solutions of radical scavengers2015

    • Author(s)
      S. Nomura, R. Furuya, K. Miyahara, T. Majima, H. Tsuchida, A. Itoh
    • Organizer
      9th International Symposium on Swift Heavy Ions in Matter (SHIM-2015)
    • Place of Presentation
      ダルムシュタット、ドイツ
    • Year and Date
      2015-05-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dissociation dynamics of multiply charged hydrocarbon molecules in fast ion collisions2014

    • Author(s)
      S. Yoshida, A. Itoh, 他4名
    • Organizer
      Asian Intersnational Seminar on Atomic Molecular Physics 2014
    • Place of Presentation
      仙台
    • Year and Date
      2014-10-06 – 2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Driving force for reversible deformation of metallic foils induced by fast heavy ion irradiation2014

    • Author(s)
      H. Minagawa, A. Itoh, 他2名
    • Organizer
      26th International Conference on Atomic Collisions in Solids
    • Place of Presentation
      Debrecen, Hungary
    • Year and Date
      2014-07-13 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Wake effects on fast molecular transmission through nanocapillaries2014

    • Author(s)
      H. Tsuchida, A. Itoh, 他13名
    • Organizer
      26th International Conference on Atomic Collisions in Solids
    • Place of Presentation
      Debrecen, Hungary
    • Year and Date
      2014-07-13 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of an experimental system for MeV ion collisions with microdroplets in vacuum2014

    • Author(s)
      T. Majima, A. Itoh, 他3名
    • Organizer
      26th International Conference on Atomic Collisions in Solids
    • Place of Presentation
      Debrecen, Hungary
    • Year and Date
      2014-07-13 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Collision experiments for biomolecules and liquid targets2013

    • Author(s)
      A. Itoh, 他4名
    • Organizer
      Ion-Surface Interactions 2013
    • Place of Presentation
      Yaroslavl, Russia
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Single-electron-capture cross-section scaling for low-q heavy ions at low energy2013

    • Author(s)
      A. Itoh, 他6名
    • Organizer
      28th International Conference on Photonic, Electronic and Atomic Collisions
    • Place of Presentation
      Lanzhou, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] Proton impact electron emission from biological molecules2012

    • Author(s)
      Y. Iriki, M. Imai, A. Itoh
    • Organizer
      8th International confernece on Swift Heavy Ions in
    • Place of Presentation
      京都大学時計台百周年記念館
    • Year and Date
      2012-10-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] Direct Measurements of multiple ionization of isolated polyatomic molecules induced by fast ion collisions2012

    • Author(s)
      T. Majima, Y. Adachi, 他7名
    • Organizer
      8th International confernece on Swift Heavy Ions in Matter
    • Place of Presentation
      京都大学時計台百周年記念館
    • Year and Date
      2012-10-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] Direct ion-irradiation of liquid targets in vacuum using capillary microprobe2012

    • Author(s)
      T. Kishimoto, S. Mori, 他4名
    • Organizer
      8th International confernece on Swift Heavy Ions in Matter
    • Place of Presentation
      京都大学時計台百周年記念館
    • Year and Date
      2012-10-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] charge-state distributions of fast diatomic carbon ions passing through a single micorcapillary2012

    • Author(s)
      J. Yokoe, S. Mori, 他6名
    • Organizer
      8th International confernece on Swift Heavy Ions in Matter
    • Place of Presentation
      京都大学時計台百周年記念館
    • Year and Date
      2012-10-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] Measurement of number spectrum of secondary electrons by using an avalanchephotodiode detector2012

    • Author(s)
      T. Nishio, T. Kishimoto, 他5名
    • Organizer
      8th International confernece on Swift Heavy Ions in Matter
    • Place of Presentation
      京都大学時計台百周年記念館
    • Year and Date
      2012-10-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] dosieter response characteristics for charged particles in BNCT2012

    • Author(s)
      T. Kawamura, R. Uchida, 他4名
    • Organizer
      8th International confernece on Swift Heavy Ions in Matter
    • Place of Presentation
      京都大学時計台百周年記念館
    • Year and Date
      2012-10-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] Production of C60 microbeams by single-microcapillary methods2012

    • Author(s)
      H. Tsuchida, T. Majima, 他9名
    • Organizer
      8th International confernece on Swift Heavy Ions in Matter
    • Place of Presentation
      京都大学時計台百周年記念館
    • Year and Date
      2012-10-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] Proton impact ionization of DNA/RNA nucleobases molecules2012

    • Author(s)
      A. Itoh and Y. Iriki
    • Organizer
      International conference on Many Particle Spectroscopy of Atoms, Clusters and Surfaces
    • Place of Presentation
      ベルリン市、コンベンションセンター
    • Year and Date
      2012-08-30
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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