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Spatially resolved spectroscopic studies of biological magnetosensitivity

Research Project

Project/Area Number 24350002
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Physical chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

WOODWARD Jonathan  東京大学, 総合文化研究科, 准教授 (80526054)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Keywordsスピン化学 / 発光分析 / クリプトクロム / ラジカル対 / 検鏡 / 生物磁気感受能 / 顕微鏡 / TOAD Microscopy / MIM microscopy / Imaging / Magnetic Field Effect / Low Field Effect / Radical Pair Dynamics / Drosophila Cryptochrome / Flavin photochemistry / 磁場効果 / ラジカル・ペア反応 / 顕微吸収分光
Outline of Final Research Achievements

This research involved the development of a new instrument for imaging the magnetic sensitivity of photochemical reactions on a submicron scale. Using this instrument, radical pairs formed from flavins (molecules believed to be at the heart of biological magnetic sensitivity) and the influence of very weak magnetic fields on their reactivity, were detected in volumes less than 4 millionths of a billionth of a liter. The microscope also allows images to be recorded that display only the regions of a sample where magnetically sensitive photochemical reactions are occurring. This technique is now being applied directly to living cells.

The new imaging microscope developed in this research will enable the study of the magnetic sensitivity of photochemical reactions in a variety of important biological and other contexts, and will help to unlock the secrets of the amazing ability of animals to sense magnetic fields.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (7 results)

All 2015 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Invited: 2 results)

  • [Journal Article] Joshua P. Beardmore, Lewis M. Antill and Jonathan R. Woodward2015

    • Author(s)
      Optical Absorption and Magnetic Field Effect Based Imaging of Transient Radicals
    • Journal Title

      Angewandte Chemie

      Volume: -

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Transient optical absorption and magnetic intensity modulation based microscopy of photochemical reaction intermediates in isolated flavins and cryptochromes2015

    • Author(s)
      Jonathan R. Woodward
    • Organizer
      2nd Kobe mini-symposium on functionalized organic molecules
    • Place of Presentation
      Kobe University, Kobe, Japan
    • Year and Date
      2015-11-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Transient optical absorption and magnetic intensity modulation based microscopy of photochemical reaction intermediates in isolated flavins and cryptochromes2015

    • Author(s)
      Jonathan R. Woodward
    • Organizer
      The Chemical Society of Japan Annual Meeting on Photochemistry 2015
    • Place of Presentation
      Sugimoto Campus, Osaka City University, Osaka, Japan
    • Year and Date
      2015-09-09 – 2015-09-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Sub-micron flavin radical and magnetic field effect based imaging2014

    • Author(s)
      Jonathan R. Woodward
    • Organizer
      APES2014.IES.SEST2014
    • Place of Presentation
      Todaiji Cultural Center, Nara Prefectural New Public Hall, Nara, Japan
    • Year and Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Towards spatially resolved MFE measurements in biological systems2013

    • Author(s)
      Woodward, Jonathan Roger
    • Organizer
      13^<th> International Symposium on Spin and Magnetic Field Effects in Chemistry and Related Phenomena
    • Place of Presentation
      Bad Hofgastein, Austria(招待講演)
    • Year and Date
      2013-04-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] Towards spatially resolved magnetic field effect measurements in biological systems

    • Author(s)
      Joshua Beardmore
    • Organizer
      第7回分子科学討論会
    • Place of Presentation
      京都テルサ(京都府民総合交流プラザ)京都府
    • Related Report
      2013 Annual Research Report
  • [Presentation] Resolving Radical Pairs : Magnetic Field Effects in Natural Environments

    • Author(s)
      Jonathan Woodward
    • Organizer
      Chemistry Department Seminar Series
    • Place of Presentation
      Chemistry Department, University of Manchester, UK
    • Related Report
      2013 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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