Nano-space functional analysis of biological molecules by IR super-resolution microscopy
| Project/Area Number |
24350003
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
SAKAI MAKOTO 東京工業大学, 資源化学研究所, 准教授 (60298172)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 超解像 / 赤外分光 / イメージング / ナノ空間 / 振動和周波 |
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| Outline of Final Research Achievements |
IR microscope is a powerful tool to measure molecular images of biological samples based on molecular information. However, microscopic objects such as biological cells cannot be measured by conventional IR microscope, because of its low spatial resolution about 10 μm. To overcome this problem, we have developed a novel type of IR super-resolution microscope based on vibrational sum-frequency generation detection. The application of this IR microscope to the biological samples was also carried out in this project.
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Report
(5 results)
Research Products
(35 results)
