Natural Product Synthesis by Utilizing Compact and Multifunctional Properties of Cyano Group
| Project/Area Number |
24350018
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Organic chemistry
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
TANINO Keiji 北海道大学, 理学研究院, 教授 (40217146)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
|---|
| Keywords | 有機化学 / 天然物化学 / 全合成 / ニトリル |
|---|
| Outline of Final Research Achievements |
The synthetic studies on Tubiferal A, Azadirachtin, and Phorbol were carried out on the basis of new reactions utilizing alkanenitriles. The unique properties of a cyano group, which is sterically compact and linear in shape, were found to be advantageous for forming carbocyclic compounds possessing hindered carbon-carbon bonds. For example, construction of the 5-7 bicyclic skeleton of Phorbol was achieved by the divinylcyclopropane rearrangement reaction of a cyanocyclopropane derivative.
|
Report
(4 results)
Research Products
(22 results)
