Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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Outline of Final Research Achievements |
The synthetic studies on Tubiferal A, Azadirachtin, and Phorbol were carried out on the basis of new reactions utilizing alkanenitriles. The unique properties of a cyano group, which is sterically compact and linear in shape, were found to be advantageous for forming carbocyclic compounds possessing hindered carbon-carbon bonds. For example, construction of the 5-7 bicyclic skeleton of Phorbol was achieved by the divinylcyclopropane rearrangement reaction of a cyanocyclopropane derivative.
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