Development of high performance bioanalytical techniques by capillary/microchip separation and detection systems
| Project/Area Number |
24350039
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
OTSUKA Koji 京都大学, 工学(系)研究科(研究院), 教授 (70183762)
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| Co-Investigator(Kenkyū-buntansha) |
KUBO Takuya 京都大学, 工学研究科, 准教授 (20374994)
NAITO Toyohiro 京都大学, 工学研究科, 助教 (10711806)
末吉 健志 京都大学, 工学研究科, 助教 (70552660)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 分離科学 / キャピラリー / マイクロチップ / 電気泳動 / クロマトグラフィー / バイオ分析 / 分離検出 / 糖鎖 |
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| Outline of Final Research Achievements |
Development of high performance bio-separation and analysis systems based on capillary electrophoresis (CE) and microchip electrophoresis (MCE) was investigated, where developments of high performance separation and detection systems using online sample concentration techniques and mass spectrometry (MS) and novel separation fields for separations of proteins and carbohydrates were mainly carried out. Following four categories were most important issues: 1) progress of high performance online sample concentration techniques; 2) improvement of the performance of MCE-MS using an interface integrated microchip with a separation channel for MCE; 3) development of CE/MCE-MS using online sample concentration techniques; 4) improving the performance of CE/MCE with novel selective separation fields.
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Report
(4 results)
Research Products
(72 results)
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[Presentation] ミクロスケール電気泳動の高機能化2014
Author(s)
内藤豊裕, 末吉健志, 久保拓也, 北川文彦, 大塚浩二
Organizer
日本分析化学会第63年会
Place of Presentation
広島大学（東広島市, 広島）
Year and Date
2014-09-17 – 2014-09-19
Related Report
Invited
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[Presentation] Novel Separation Media and Materials for Microscale Separations2014
Author(s)
Kyosuke Nii, Yoshiki Murakami, Toyohiro Naito, Kenji Sueyoshi, Takuya Kubo, Madoka Takai, Koji Otsuka
Organizer
41st International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC2014 New Orleans)
Place of Presentation
New Orleans, LO, USA
Year and Date
2014-05-11 – 2014-05-15
Related Report
Invited
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[Presentation] Strategies for improving analytical performance of microscale electrophoresis2013
Author(s)
Hiroshi Koino, Yudai Fukushima, Hiroya Ota, Koichi Kanemori, Takayuki Kawai, Kenji Sueyoshi, Takuya Kubo, Fumihiko Kitagawa, Koji Otsuka
Organizer
40th International Symposium on Liquid-Phase Separations and Related Techniques (HPLC2013 Hobart)
Place of Presentation
Hobart, Tasmania, Australia
Related Report
Invited
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