| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
The development of much stronger organobase is highly demanded to overcome intrinsic limitation of applicable pro-nucleophiles which have relatively acidic proton at the alpha-position, such as 1,3-dicarbonyl compounds and nitroalkanes. In general, the basicity of the organobases increases with increasing the resonance stability of their conjugate acids, the protonated form of the organobases. For instance, introduction of phosphazene or guanidine subunit(s) to the iminophosphorane core stabilizes its conjugate acid, aminophosphonium cation, to afford a series of phosphazene organosuperbases. However, the iminophosphorane modified by the additional phosphazene or guanidine subunit has never been applied to develop chiral organosuperbase so far. We hence designed a pseudo C2-symmetric P3-phosphazen and bis(guanidino)iminophosphorane as a novel family of chiral phosphazene organosuperbases and successfully developed these molecules.
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