| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
A variety of novel chiral silicon molecules were synthesized in optically active form by highly enantioselective asymmetric desymmetrization of achiral silicon molecules and further stereoselective transformations. 1) Enantioselective hydrosilylation of dihydrosilanes with a chiral platinum catalyst afforded chiral alkenylhydrosilanes in optically active form up to 86% ee, which were converted into chiral silanols in highly stereoselective manner. 2) Enantioselective beta-elimination of silacyclopentene oxides with a novel chiral lithium amide afforded chiral silacyclopentenols in optically active form up to >98% ee, which were converted in to a variety of chiral silacyclopentane derivatives. One of the synthesized silacyclopentane derivatives showed substantial binding activity to a serotonin receptor protein, in which the silicon chirality is the key structural factor for the binding activity.
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