Chirality amplification through unique crystallization - supersaturated solution, melt and crystal co grinding
| Project/Area Number |
24350064
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional materials chemistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
KURODA REIKO 東京理科大学, 総合研究機構, 教授 (90186552)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | キラリティー / 結晶工学 / 結晶成長 / 超分子結晶 / 結晶多形 / 超分子 |
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| Outline of Final Research Achievements |
100% chirality amplification was achieved by crystallization of super-cooled melt of 2-(4-chlorophenylthio)-3-methyl-2-cyclohexen-1-one) (p-Cl) which always produces achiral crystals from conventional crystallization, using one chiral crystal of its methyl analogue as a seed. Chiral crystals thus induced however go back to the achiral form by facile thermal or mechanical stimuli. The reason underneath was studied with DSC and DFT calculation. Photocyclization reaction of the chiral crystals of p-Cl exhibited enantio-selectivity at its early stage.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Heteroleptic Ru(II) complexes containing aroyl hydrazone and 2,2’-bipyridyl: Synthesis, X-ray crystal structures, electrochemical and DFT studies2014
Author(s)
B.Ghosh, S. Naskar, S. Naskar, A. Espinosa. J. Yau, T. C. Mak, R. Sekiya, R. Kuroda, S. K. Chattopadhyay
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Journal Title
Polyhedron
Volume: 72
Pages: 115-121
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Synthesis, Characterization, X-ray Crystal Structure, DFT Calculations, and Catalytic Properties of a Dioxidovanadium(V) Complex Derived from Oxamohydrazide and Pyridoxal: A Model Complex of Vanadate-Dependent Bromoperoxidase2014
Author(s)
C. Das, P. Adak, S. Mondal, R. Sekiya, R. Kuroda, S. I. Gorelsky, and S. K. Chattopadhyay
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Journal Title
Inorg. Chem.
Volume: 53
Issue: 21
Pages: 11426-11437
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Molecular recognition of a large bisphenol A derivative,α,α'-bis(4-hydroxyphenyl)-1,4-diisopropylbenzene, using p-benzoquinone derivatives2014
Author(s)
N. Iwase, Y. Shigeno, T. Wakabayashi, T. Sato, N. Tajima, R. Kuroda and Y. Imai, CrystEngComm, 16, 159-163 (2014)
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Journal Title
CrystEngComm
Volume: 16
Issue: 2
Pages: 159-163
DOI
Related Report
Peer Reviewed
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[Journal Article] Nonclassical tunability of solid-state CD and CPL properties of chiral 2-naphthale necarboxylic acid/amine supramolecular organic fluorophore2012
Author(s)
Nishiguchi, N.; Kinuta, T.; Sato, T.; Nakano, Y.; Tokutome, H.; Tajima, N.; Fujiki, M.; Kuroda, R.; Matsubara, Y.; Imai, Y.
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Journal Title
Chem.Asian J.
Volume: 7
Issue: 2
Pages: 360-366
DOI
Related Report
Peer Reviewed
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[Presentation] 右と左からみた生命の世界2015
Author(s)
黒田玲子
Organizer
生命の起原および進化学会
Place of Presentation
東京都葛飾区 東京理科大学葛飾キャンパス
Year and Date
2015-03-15
Related Report
Invited
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