| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Outline of Final Research Achievements |
A potential one-step process to 6-membered carbocyclic compound, 2-deoxy-scyllo-inosose, from D-glucose comprising one-pot incubation of D-glucose with recombinant 2-deoxy-scyllo-inosose synthase (BtrC) and polyphosphate glucokinase in the presence of polyphosphate and NAD+ was developed. It should be emphasized here that the present approach has significant potential for the production of 6-membered carbocyclic compound from widely available D-glucose and further implies significant opportunity for developing acceptable ‘green’ ways for the production of organochemical resources from sustainable agricultural and biomass products by utilizing enzymes involved in natural product biosynthesis.
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