Investigation on biological activity of cyclic dinucleotides and elucidation of mechanism how the activity is expressed, directing toward invention of new immunostimulants
| Project/Area Number |
24350087
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Aichi Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Nishimura Akiko 愛知工業大学, 工学部, 准教授 (90609322)
Ohta Michio 椙山女学園大学, 看護学部, 教授 (20111841)
Hyodo Mamoru 愛知工業大学, 工学部, 講師 (30548186)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Keywords | 環状ジヌクレオチド / c-di-GMP / 2',3'-cGAMP / 免疫活性 / がん細胞増殖抑制 / STING / 免疫 / バイオフィルム / がん / ガン免疫療法 / がん免疫療法 / c[G(3'-5')pA(3'-5')p] / c[G(2'-5')pA(3'-5')p] / 核酸 / 癌 / Riboswitch / ワクチン / 生理活性 |
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| Outline of Final Research Achievements |
We analyzed the physiological activity of bis (3'-5') cyclic diguanylic acid（c-di-GMP）and other cyclic dinucleotides having similar structure. Our results demonstrated the important bioactivity of c-di-GMP to inhibit the metastases of breast cancer and to attenuate experimental autoimmune encephalitis. During the immune response against cytosolic DNA, cyclic-GMP-AMP (cGAMP) was proposed to bind to an immunoreceptor called STING. Here we demonstrated that non-canonical cyclic dinucleotides 2',3'-cGAMP, which contains a single 2’-5’ phosphodiester bond, activated STING and induced the production of type I interferons.
These are valuable findings for the development of the research and our final goal ”invention of useful immunostimulator”.
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Report
(5 results)
Research Products
(19 results)
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[Journal Article] Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING.2015
Author(s)
Kobayashi H, Kobayashi CI, Nakamura-Ishizu A, Karigane D, Haeno H, Yamamoto KN, Sato T, Ohteki T, Hayakawa Y, Barber GN, Kurokawa M, Suda T, and Takubo K.
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Journal Title
Cell Reports
Volume: 111
Issue: 1
Pages: 71-84
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Activation of the Stimulator of Interferon Genes (STING) adaptor attenuates experimental autoimmune encephalitis.2014
Author(s)
Henrique Lemos, Lei Huang, Phillip R. Chandler, Eslam Mohamed, Guilherme R. Souza, Lingqian Li, Gabriela Pacholczyk, Glen N. Barber, Yoshihiro Hayakawa, David H. Munn, and Andrew L. Mellor
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Journal Title
J. Immunology
Volume: 192
Issue: 12
Pages: 5571-5578
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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