| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
A single-molecular detection system utilizing our original nanomechanical DNA origami devices (DNA pliers) composed of two 170-nm long stick-like components connected to each other at a fulcrum has been applied to more practical use by improving the molecular design and nanomechanical properties. DNA pliers can now detect protons, theoretically smallest substance, as well as special binding event of bio-related molecules such as PNA strand invasion. Introduction of a tubular design enabled handy detection of structure change of DNA pliers with popularly available gel electrophoresis.
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