Fundamental study on the luminescent properties of the inorganic hollow phosphors to contribute to the drug delivery system
| Project/Area Number |
24350098
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional materials/Devices
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
JIN Tetsuro 独立行政法人産業技術総合研究所, ユビキタスエネルギー研究部門, 主任研究員 (30357248)
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| Co-Investigator(Kenkyū-buntansha) |
OCHIISHI Tomoyo 産業総合技術研究所, バイオメディカル研究部門, 主任研究員 (30356729)
YAZAWA Tetsuo 兵庫県立大学, 大学院工学研究科, 教授 (50347522)
DAIKO Yusuke 名古屋工業大学, 大学院工学研究科, 助教 (70514404)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | 希土類蛍光体 / ドラッグデリバリーシステム / 分相 / ガラス / 表面改質 / 生体親和性 / 中空粒子 / ナノ材料 / 分相ガラス / 蛍光特性 |
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| Outline of Final Research Achievements |
Neutron capture therapy (NCT) is one of available ways for intractable cancers in human body. BNCT is in practical use, in addition, gadolinium neutron capture therapy (GdNCT) is also useful because Gd ion has a toxicity against human calls by gamma-ray generation under irradiation thermal neutrons. Using a lanthanide phosphor including Gd synthesized by our technique, the phosphors are able to form unique shapes such as hollow sphere, and the phosphor showing a good emission can be used as a new type drug delivery system (DDS) possessing several functions such as gamma-ray generation under irradiation of thermal neutron, drug delivery and lavel of the tumor cells in one material. In this study, the preparation of hollow sphere lanthanide phosphor was performed using polymer beads as a template by hydrothermal treatment. And then the tumor cell killing effect of this material against cultured the cancer cell after irradiation of thermal neutron and incubation was investigated.
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Report
(4 results)
Research Products
(14 results)
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[Presentation] 希土類蛍光体中空粒子の表面改質の検討2014
Author(s)
神哲郎・落石知世・渋谷有里・矢澤哲夫
Organizer
第２７回日本セラミックス協会秋季シンポジウム
Place of Presentation
鹿児島大学郡元キャンパス（鹿児島市）
Year and Date
2014-09-09 – 2014-09-11
Related Report
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[Presentation] 希土類蛍光体中空粒子の応用2014
Author(s)
神哲郎・落石知世・渋谷有里・矢澤哲夫
Organizer
希土類討論会
Place of Presentation
東京都江戸川区タワーホール（東京都）
Year and Date
2014-05-22 – 2014-05-23
Related Report
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