Spatio-temporal analysis of blood flow in bifurcation of blood vessel using ultrasonic-measurement-integrated simulation

• Project/Area Number: 24360064
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Fluid engineering
• Research Institution: Tohoku University
• Principal Investigator: HAYASE Toshiyuki 東北大学, 流体科学研究所, 教授 (30135313)
• Co-Investigator(Kenkyū-buntansha): OBAYASHI Shigeru 東北大学, 流体科学研究所, 教授 (80183028) ; SAIJO Yoshifumi 東北大学, 医工学研究科, 教授 (00292277)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2012: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
• Keywords: バイオ流体力学 / 計測融合シミュレーション / 超音波計測 / 血流動態 / 脈波 / 計測融合解析

Outline of Final Research Achievements

It has been pointed out that hemodynamics has a strong relationship with occurrence and development of circulatory diseases. However primary parameter to these diseases is still unknown. This research was conducted for a simultaneous analysis of blood pressure (BP) and flow in a carotid artery using photoplethysmography (PPG) and two-dimensional ultrasonic-measurement-integrated (2D-UMI) simulation. The system analyzes BP and flow fields from the viewpoint of influence of phases of BP and flow corresponding to forward and backward waves on vessel wall. The simultaneous analysis system using PPG and 2D-UMI simulation was developed, and characteristics of the blood flow field in a carotid artery was clarified focusing on time variation of the phase corresponding to forward and backward waves identified by wave intensity (WI).

Research Products

• [Journal Article] Blood flow analysis in carotid artery bifurcation by two-dimensional ultrasonic-measurement-integrated simulation (2015)
  • Author(s): Hiroko Kadowaki, Toshiyuki Hayase, Kenichi Funamoto, Shusaku Sone, Tadashi Shimazaki, Takao Jibiki, Koji Miyama
  • Journal Title: Journal of Biomechanical Science and Engineering Volume: 10 Issue: 1 Pages: 14-00266-14-00266
  • DOI: 10.1299/jbse.14-00266
  • NAID: 130004691140
  • ISSN: 1880-9863
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Development and feasibility study of a two-dimensional ultrasonic-measurement-integrated blood flow analysis system for hemodynamics in carotid arteries (2014)
  • Author(s): Takaumi Kato, Kenichi Funamoto, Toshiyuki Hayase, Shusaku Sone, Hiroko Kadowaki, Tadashi Shimazaki, Takao Jibiki, Koji Miyama, Lei Liu
  • Journal Title: Medical & Biological Engineering & Computing Volume: 52 Issue: 11 Pages: 933-943
  • DOI: 10.1007/s11517-014-1193-3
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Reproduction of pressure field in ultrasonic- measurement-integrated simulation of blood flow (2012)
  • Author(s): Kenichi Funamoto and Toshiyuki Hayase
  • Journal Title: International Journal for Numerical Methods In Biomedical Engineering Volume: ２９ Issue: 7 Pages: 1-15
  • DOI: 10.1002/cnm.2522
  • Peer Reviewed
• [Presentation] 超音波計測と計測融合シミュレーションによる血圧場と血流場の同時解析システム (2015)
  • Author(s): 曾根周作，早瀬敏幸，船本健一，白井敦
  • Organizer: 日本機械学会第27回バイオエンジニアリング講演会
  • Place of Presentation: 新潟
  • Year and Date: 2015-01-10
• [Presentation] 2次元超音波計測融合シミュレーションシステムにおける解析精度の実験的検証 (2015)
  • Author(s): 門脇弘子，早瀬敏幸，船本健一，井上浩介，島崎正，地挽隆夫，見山広二
  • Organizer: 日本機械学会第27回バイオエンジニアリング講演会
  • Place of Presentation: 新潟
  • Year and Date: 2015-01-09
• [Presentation] 3次元非定常の超音波計測融合血流解析における圧力場の再現に関する検討 (2015)
  • Author(s): 船本 健一, 早瀬 敏幸
  • Organizer: 日本機械学会第27回バイオエンジニアリング講演会
  • Place of Presentation: 新潟
  • Year and Date: 2015-01-09
• [Presentation] 2次元超音波計測融合シミュレーションによる頸動脈分岐部の血流解析 (2014)
  • Author(s): 門脇弘子，早瀬敏幸，船本健一，曾根周作，島崎正，地挽隆夫，見山広二
  • Organizer: 計測自動制御学会東北支部50周年記念学術講演会
  • Place of Presentation: 仙台
  • Year and Date: 2014-12-11
• [Presentation] 超音波計測融合シミュレーションにおける血流量推定手法の有効性の検証 (2014)
  • Author(s): 門脇弘子，早瀬敏幸，船本健一，曾根周作，島崎正，地挽隆夫，見山広二
  • Organizer: 日本流体力学会年会2014
  • Place of Presentation: 仙台
  • Year and Date: 2014-09-17
• [Presentation] 光電容積脈波計測と超音波計測融合シミュレーションによる頸動脈内の血圧と血流場の同時解析 (2014)
  • Author(s): 曾根 周作, 早瀬 敏幸, 船本 健一, 白井 敦
  • Organizer: 日本流体力学会年会2014
  • Place of Presentation: 仙台
  • Year and Date: 2014-09-17
• [Presentation] Simultaneous Analysis System for Blood Pressure and Flow Using Ultrasonic-Measurement-Integrated Simulation (2014)
  • Author(s): Shusaku Sone, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai
  • Organizer: 7th World Congress of Biomechanics
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-07-11
• [Presentation] 光電脈波計測と超音波計測融合解析による血圧血流同時計測システムによるWI解析 (2014)
  • Author(s): 曾根周作、早瀬敏幸、船本健一、白井敦
  • Organizer: 日本超音波医学会第87回学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-05-09
• [Presentation] 超音波計測融合シミュレーションにおける血流量推定精度の向上 (2014)
  • Author(s): 門脇弘子，早瀬敏幸，船本健一，曾根周作，島崎正，地挽隆夫，見山広二，劉磊
  • Organizer: 日本超音波医学会第87回学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-05-09
• [Presentation] 超音波計測融合シミュレーションによる血液粘度の推定 (2013)
  • Author(s): 門脇弘子,船本健一,早瀬敏幸,曾根周作,小笠原正文,地挽隆夫,橋本浩,見山広二,劉磊
  • Organizer: 日本機械学会第25回バイオエンジニアリング講演会
  • Place of Presentation: つくば市
  • Year and Date: 2013-01-10
• [Presentation] 小動物用超音波計測連成解析システムによるマウスの頸動脈の血流解析 (2013)
  • Author(s): 坂西山河,早瀬敏幸,船本健一,曾根周作
  • Organizer: 日本機械学会第25回バイオエンジニアリング講演会
  • Place of Presentation: つくば市
  • Year and Date: 2013-01-10
• [Presentation] 総頸動脈内の3次元血流場に対する2次元超音波計測融合シミュレーションの解析精度の検証 (2013)
  • Author(s): 松本拓也,船本健一,早瀬敏幸
  • Organizer: 日本機械学会第25回バイオエンジニアリング講演会
  • Place of Presentation: つくば市
  • Year and Date: 2013-01-10
• [Presentation] Measurement-Integrated Simulation for Fundamental Flow Analysis and Real Flow Applications (2013)
  • Author(s): Ｔｏｓｈｉｙｕｋｉ Ｈａｙａｓｅ
  • Organizer: International Workshop on Flow Dynamics Related to Energy, Aerospace and Material Science
  • Place of Presentation: ストックホルム，スウェーデン
  • Invited
• [Presentation] 小動物用超音波計測連成解析システムにおける血管形状抽出の高精度化 (2012)
  • Author(s): 坂西山河,早瀬敏幸,船本健一,曾根周作
  • Organizer: 日本機械学会第23回バイオフロンティア講演会
  • Place of Presentation: 弘前
  • Year and Date: 2012-10-06
• [Presentation] 2次元超音波計測融合シミュレーションによる頸動脈分岐部の血流解析 (2012)
  • Author(s): 門脇弘子,船本健一,早瀬敏幸,曾根周作,小笠原正文,地挽隆夫,橋本浩,見山広二
  • Organizer: 日本機械学会第23回バイオフロンティア講演会
  • Place of Presentation: 弘前
  • Year and Date: 2012-10-05
• [Presentation] 超音波計測融合血流シミュレーションシステムの開発 (2012)
  • Author(s): 早瀬敏幸
  • Organizer: 第21回日本形成外科学会基礎学術集会
  • Place of Presentation: 猪苗代(招待講演)
  • Year and Date: 2012-10-05
• [Presentation] 実験計測と数値解析の融合流体解析 (2012)
  • Author(s): 早瀬敏幸
  • Organizer: 日本機械学会2012年度年次大会
  • Place of Presentation: 金沢(招待講演)
  • Year and Date: 2012-09-10
• [Presentation] 視覚協創学(9) : 視覚協創による血流動態のリアライゼーション (2012)
  • Author(s): 早瀬敏幸,船本健一,曾根周作,坂西山河
  • Organizer: 計算工学講演会
  • Place of Presentation: 京都
  • Year and Date: 2012-05-30
• [Presentation] 2次元超音波計測融合シミュレーションによる頸動脈分岐部の非定常血流量推定 (2012)
  • Author(s): 門脇弘子,船本健一,早瀬敏幸,曾根周作,小笠原正文,地挽隆夫,橋本浩,見山広二, 超音波医学
  • Organizer: 日本超音波医学会第85回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-25
• [Presentation] Simultaneous Analysis System for Blood Pressure and Flow Using Photoplethysmography and Ultrasonic-Measurement-Integrated Simulation
  • Author(s): Shusaku Sone, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai
  • Organizer: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'13)
  • Place of Presentation: 大阪
• [Presentation] Improvement of Simultaneous Analysis System for Blood Pressure and Flow Velocity Using Photoplethymography and Ultrasonic-Measurement-Integrated Simulation
  • Author(s): Shusaku Sone, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai
  • Organizer: 7th East Asian Consortium on Biomedical Engineering
  • Place of Presentation: 台北，台湾
• [Presentation] Consideration on the Evaluation Function of Blood Flow Rate Estimation in Ultrasonic-Measurement-Integrated Simulation
  • Author(s): Hiroko Kadowaki, Toshiyuki Hayase, Kenichi Funamoto, Shusaku Sone, Takao Jibiki, Hiroshi Hashimoto, Koji Miyama and Lei Liu
  • Organizer: 7th East Asian Consortium on Biomedical Engineering
  • Place of Presentation: 台北，台湾
• [Presentation] The effect of axial variation of the plane flow rate on two-dimensional ultrasonic-measurement-integrated simulation of blood flow in a common carotid artery
  • Author(s): Takuya Matsumoto, Kenichi Funamoto, Toshiyuki Hayase
  • Organizer: 15th International Conference on Biomedical Engineering
  • Place of Presentation: シンガポール，シンガポール
• [Presentation] Validation of blood vessel geometry reconstruction and of blood flow analysis by ultrasonic-measurement-integrated flow-structure interaction simulation system for small animals
  • Author(s): Toshiyuki Hayase, Kenichi Funamoto, Shusaku Sone
  • Organizer: 15th International Conference on Biomedical Engineering
  • Place of Presentation: シンガポール，シンガポール
• [Remarks] http://www.ifs.tohoku.ac.jp/sme/index-j.htm
• [Remarks] 東北大学流体科学研究所融合計算医工学研究分野
  • URL: http://www.ifs.tohoku.ac.jp/sme/index-j.htm
• [Patent(Industrial Property Rights)] 超音波診断装置および血流量推定プログラム (2012)
  • Inventor(s): 早瀬敏幸、船本健一、門脇弘子
  • Industrial Property Rights Holder: 国立大学法 人東北大学
  • Industrial Property Number: 2012-116544
  • Filing Date: 2012-05-22