Evaluation of cavitation from bubble mist and development to sonopolation

• Project/Area Number: 24360155
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Measurement engineering
• Research Institution: Gunma University
• Principal Investigator: YAMAKOSHI Yoshiki 群馬大学, 大学院理工学府, 教授 (10174640)
• Co-Investigator(Kenkyū-buntansha): SUNAGUCHI Naoki 群馬大学, 大学院理工学府, 助教 (60536481) ; 三輪 空司 群馬大学, 大学院・工学研究科, 准教授 (30313414)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: ドラッグデリバリシステム / 音響放射圧 / 気泡クラウド / 気泡ミスト / キャビテーション / 微小気泡 / 気泡トラッピング / ソノポレーション / 超音波 / マニピュレーｼｮﾝ / 血流依存性血管拡張反応 / 微小血管系 / 加圧光センサ法 / 生体光センシング / 酸化還元ヘモグロビン / プレスチモグラフ

Outline of Final Research Achievements

Ultrasonic wave assisted drug delivery system which uses micro bubbles of less than several microns in diameter including medicine is effective because sonopolation which makes small pores on the cell membrane can be applied for the injection of dug into the cell. Purpose of this research is that cavitation from bubble cloud is evaluated and a method in order to improve the efficiency of sonoporation is developed. By evaluation of bubble cloud dynamics under high intensity ultrasonic wave irradiation using optical observation by high speed camera, an optimum ultrasonic wave irradiation sequence for bubble cloud cavitation is proposed. In-situ observation of bubble cloud cavitation and ultrasonic wave field visualization method which are important tools in ultrasonic wave assisted drug delivery system are developed. These methods uses ultrasonic power Doppler imaging method to visualize the sound field and the bubble cloud cavitation.

Research Products

• [Journal Article] Improvement in microhollow production using bubble cloud cavitation by dual-frequency ultrasonic wave irradiation (2014)
  • Author(s): Naoki Sunaguchi, Jun Yamaguchi, Takuya Kanai, Tomoaki Isono, and Yoshiki Yamakoshi
  • Journal Title: Japanese Journal of Applied Physics Volume: 53 Issue: 7S Pages: 07KF18-07KF18
  • DOI: 10.7567/jjap.53.07kf18
  • NAID: 210000144269
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 工学から見たDDS超音波治療 (2014)
  • Author(s): 山越芳樹、砂口尚輝
  • Journal Title: 超音波テクノ Volume: 26 Pages: 65-70
  • Peer Reviewed / Open Access
• [Journal Article] Simultaneous Observation of Bubble Clouds and Microhollows Produced by Bubble Cloud Cavitation (2013)
  • Author(s): Yoshiki Yamakoshi, Jun Yamaguchi, Tomoyuki Ozawa, Tomoaki Isono, and Takuya Kanai
  • Journal Title: Japanese Journal of Applied Physics Volume: 52
  • NAID: 210000142533
  • Peer Reviewed
• [Journal Article] 気泡クラウドと微小窪みの同時観察による気泡クラウドキャビテーションの評価 (2013)
  • Author(s): 山越芳樹・砂口尚輝
  • Journal Title: 超音波テクノ Volume: 25 Pages: 1-6
• [Journal Article] Characterization of skin dermis microcirculation in flow-mediated dilation using optical sensor with pressurization mechanism (2013)
  • Author(s): Y. Yamakoshi, K. Kotani, N. Taniguchi, T. Miwa
  • Journal Title: Med. Biol. Eng. Comput. Volume: 51 Pages: 497-505
  • Peer Reviewed
• [Presentation] 音響穿孔のための微小気泡評価法の提案 (2014)
  • Author(s): 永井隼人，礒野智章，砂口尚輝，山越芳樹
  • Organizer: 日本超音波医学会第87回学術集会
  • Place of Presentation: パシフィコ横浜（横浜）
  • Year and Date: 2014-05-09
• [Presentation] 複数同時超音波照射による気泡クラウドキャビテーション (2014)
  • Author(s): 泉 遥介，金井拓也，砂口尚輝，山越芳樹
  • Organizer: 日本超音波医学会第87回学術集会
  • Place of Presentation: パシフィコ横浜（横浜）
  • Year and Date: 2014-05-09
• [Presentation] 工学から見たDDS超音波治療 -超音波DDSの課題と将来展望-
  • Author(s): 山越芳樹
  • Organizer: 日本超音波医学会第86回学術集会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 複数超音波の同時照射による気泡クラウドキャビテーションの評価
  • Author(s): 砂口尚輝、山口淳、金井拓也、礒野智章、山越芳樹
  • Organizer: 第34回超音波エレクトロニクスの基礎と応用に関するシンポジウム
  • Place of Presentation: 京都