| Project/Area Number |
24360160
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Measurement engineering
|
|---|
| Research Institution | Toyohashi University of Technology |
|---|
Principal Investigator |
HOZUMI Naohiro 豊橋技術科学大学, 国際協力センター, 教授 (30314090)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TANAKA Naohiko 芝浦工業大学, システム工学部, 教授 (10255648)
YOSHIDA Sachiko 豊橋技術科学大学, 工学系研究科, 講師 (40222393)
YAMAMOTO Seiji 浜松医科大学, メディカルフォトニクス研究センター, 教授 (60144094)
SAIJO Yoshifumi 東北大学, 医工学研究科, 教授 (00292277)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Kazuto 本多電子株式会社, メディカル事業部, 部長
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
|
|---|
| Keywords | 超音波顕微鏡 / 生体組織 / 粘弾性イメージング / 弾性イメージング |
|---|
| Outline of Final Research Achievements |
We have proposed the acoustic microscope for viscoelastic imaging by utilizing both pressure and shear waves focused on the target. The specimen was placed on an acrylic plaque substrate. Pulsed pressure and shear waves with frequency range of 40 - 120 MHz were sequentially produced in the substrate and focused on the top surface of the substrate where the specimen was attached. The shear wave was produced when the pressure wave in water comes into the substrate with oblique incidence. Reflections were interpreted into bulk modulus, shear modulus and viscosity. Mechanical scan made it possible to acquire 2D profiles of these three parameters. A cancerous liver of rat was quantitatively observed. 2D profiles of bulk modulus, shear modulus and viscosity were displayed. Among these three profiles viscosity profile successfully highlighted the cancerous region. A good agreement with optical image was seen after staining with antibody.
|
