| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Outline of Final Research Achievements |
The primary objective in this study is to control the crystallinity and desorption rate of synthetic hydroxyapatite (HAp) for tissue-engineering scaffold, aiming to improve its bioresorbability and to promote bone regeneration. We prepared the calcium phosphate-based materials having hierarchical structure and multi-functions and consequently provided a structure-based interpretation for their in vitro biodegradation behaviours. HAp nanorod arrays were prepared on a series of soda lime silicate glasses in phosphate aqueous solutions via a glass conversion process. The partial substitution of strontium ion for calcium ion in the HAp crystal lattice can modify the composition and morphology of HAp nanorods, making it possible to design HAp nanorod array structure with c-axis orientation of enhanced biodegradability. The in vitro biodegradation profiles were explained using a heterogeneous structure (biphasic) model consisting of both ordered and disordered phases.
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