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Development of new biodegradable implant materials based on the intermetallic compounds

Research Project

Project/Area Number 24360290
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Structural/Functional materials
Research InstitutionOsaka University

Principal Investigator

HAGIHARA KOJI  大阪大学, 工学(系)研究科(研究院), 准教授 (10346182)

Co-Investigator(Renkei-kenkyūsha) NAKANO Takayoshi  大阪大学, 大学院工学研究科, 准教授 (30243182)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Keywords生体内溶解性材料 / Mg合金 / Ca合金 / 金属間化合物 / 溶解挙動 / 生体親和性 / 力学特性 / 溶解性 / インプラント / 生体材料 / Zn合金
Outline of Final Research Achievements

Development of biodegradable metallic implants that eliminate the need of a second operation for removal has been strongly desired. As a new candidate, we focused the use of intermetallic compounds. In intermetallic compounds, different atomic species occupy designated lattice sites, and are typically held together by strong bonds. The variations in bond properties between the varying atomic species were expected to control the degradation behavior of the material. In this study we focused on the Ca-Mg-Si and Ca-Mg-Zn ternary systems. As a result, the control of the degradation behavior by forming compounds was actually accomplished as expected. Especially, in Ca-Mg-Zn compounds, the formation of Zn-containing oxide as a protective layer against corrosion on the specimen surfaces was found to strongly affect their corrosion properties.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (16 results)

All 2015 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Invited: 1 results) Book (4 results)

  • [Journal Article] Degradation behavior of Ca-Mg-Zn intermetallic compounds for use as biodegradable implant materials2014

    • Author(s)
      K. Hagihara, S. Shakudo, K. Fujii and T. Nakano
    • Journal Title

      Materials Science and Engineering C

      Volume: 44 Pages: 285-292

    • DOI

      10.1016/j.msec.2014.08.037

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Possibility of Mg- and Ca-based intermetallic compounds as new biodegradable implant materials2013

    • Author(s)
      K. Hagihara, K. Fujii, A. Matsugaki, T. Nakano
    • Journal Title

      Materials Science and Engineering C

      Volume: 33 Issue: 7 Pages: 4101-4111

    • DOI

      10.1016/j.msec.2013.05.055

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 生体疑似溶液中でのMg 単結晶溶解挙動の結晶方位依存性2015

    • Author(s)
      大久保政欣,萩原幸司,中野貴由
    • Organizer
      日本金属学会 2015 春期講演大会
    • Place of Presentation
      東京大学
    • Year and Date
      2015-03-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mg単結晶の溶解挙動の結晶方位依存性2014

    • Author(s)
      大久保政欣,萩原幸司,中野貴由
    • Organizer
      軽金属学会関西支部 若手研究者・院生による研究発表会
    • Place of Presentation
      関西大学
    • Year and Date
      2014-12-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ca-Mg-Zn 基化合物複相合金の溶解挙動2014

    • Author(s)
      赤土周平,大久保政欣,萩原幸司,中野貴由
    • Organizer
      日本金属学会 2014 秋期講演大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2014-09-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 溶解性インプラント材料としての(Ca, Mg)基金属間化合物2012

    • Author(s)
      藤井健太, 萩原幸司, 松垣あいら, 中野貴由
    • Organizer
      2012年度軽金属学会関西支部 若手研究者・院生による発表研究会
    • Place of Presentation
      大阪工業大学
    • Year and Date
      2012-12-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] 生体内溶解性構造材料としての(Ca, Mg, Zn)基金属間化合物の可能性2012

    • Author(s)
      藤井健太, 萩原幸司, 松垣あいら, 中野貴由
    • Organizer
      日本バイオマテリアル学会大会シンポジウム2012
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2012-11-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] (Ca, Mg, Zn)基生体内溶解性金属間化合物の開発2012

    • Author(s)
      藤井健太, 萩原幸司, 松垣あいら, 中野貴由
    • Organizer
      第151回日本金属学会秋期講演大会
    • Place of Presentation
      愛媛大学城北キャンパス
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] (Ca,Mg,Zn)系金属間化合物合金の溶解挙動

    • Author(s)
      赤土 周平, 萩原 幸司, 中野 貴由
    • Organizer
      日本金属学会 2013 秋期講演大会
    • Place of Presentation
      金沢大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 長周期構造相の結晶構造と塑性変形挙動

    • Author(s)
      萩原幸司
    • Organizer
      日本金属学会 2013 秋期講演大会
    • Place of Presentation
      金沢大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Ca-Mg-Zn系金属間化合物生体内溶解材料の創成

    • Author(s)
      赤土周平,萩原幸司,中野貴由
    • Organizer
      軽金属学会関西支部 若手研究者・院生による研究発表会
    • Place of Presentation
      兵庫県立大
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ca-Mg-Zn系新規生体内溶解性単相・複相合金の創成

    • Author(s)
      赤土周平,萩原幸司,中野貴由
    • Organizer
      日本金属学会 2014 春期講演大会
    • Place of Presentation
      東京工業大学
    • Related Report
      2013 Annual Research Report
  • [Book] バイオマテリアル研究の最前線  著者執筆項目:4-2-1. 新たな(Mg,Ca)基生分解性金属材料の開発2014

    • Author(s)
      萩原幸司 (分担執筆)
    • Publisher
      日本金属学会
    • Related Report
      2014 Annual Research Report
  • [Book] バイオマテリアル研究の最前線 著者執筆項目:2-3-3. 薬事認可されたβ型Ti-15Mo-5Zr-3Al合金単結晶の塑性挙動の解明2014

    • Author(s)
      萩原幸司 (分担執筆)
    • Publisher
      日本金属学会
    • Related Report
      2014 Annual Research Report
  • [Book] 未来型人工関節を目指して-その歴史から将来展望まで-  (編集:吉川秀樹、中野貴由、松岡厚子、中島義雄)2013

    • Author(s)
      萩原幸司 (分担執筆)
    • Publisher
      日本医学館
    • Related Report
      2013 Annual Research Report
  • [Book] 未来型人工関節を目指して-その歴史から将来展望まで-(編集 : 吉川秀樹、中野貴由、松岡厚子、中島義雄)

    • Author(s)
      萩原幸司(分担執筆)
    • Publisher
      日本医学館(in press)
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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