Molecular Hysteresis Recognition Gating Membrane and Multi-Mode Expression
| Project/Area Number |
24360326
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Reaction engineering/Process system
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
YAMAGUCHI Takeo 東京工業大学, 資源化学研究所, 教授 (30272363)
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| Co-Investigator(Kenkyū-buntansha) |
TAMAKI Takanori 東京工業大学, 資源化学研究所, 講師 (80567438)
OHASHI Hidenori 東京工業大学, 資源化学研究所, 助教 (00541179)
OHSHIBA Yuhei 東京工業大学, 資源化学研究所, 助教 (10708530)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | hysteresis recognition / molecular recognition / gating membrane / multi-mode / bio-inspired / 履歴認識 / ゲート膜 / ポリアンフォライト / 分子認識 / 透過特性 / 自律膨潤収縮 / 履歴 / 機能膜 / プラズマグラフト重合 / パーオキサイド基 / 分子シグナル / 多重相 / 信号増幅 / グラフトポリマー固定化膜 |
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| Outline of Final Research Achievements |
In the present study, to reproduce the sophisticated function of hysteresis recognition in living body, a novel membrane of ion recognition polyampholyte gating membrane was developed. The membrane was fabricated by grafting ion recognition polyampholytes onto the pore surface of a porous polyethylene substrate. The ion recognition polyampholyte comprises polyampholyte having both of positive/negative charges (known to take multi-phase in response to pH hysteresis) and crown ether moiety (known as specific receptor for signal ions). The developed gating membrane was found to have response properties to environmental hysteresis. Furthermore, the membrane exhibits chemical logistic gating property in response to two signals of pH and recognizable ion.
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Report
(4 results)
Research Products
(88 results)
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[Presentation] Control of P450cam Activity with the Avidin Recognition2012
Author(s)
Yuhei Oshiba, Takanori Tamaki, Hidenori Ohashi, Taichi lto, Hidehiko Hirakawa, Satoshi Yamaguchi, Teruyuki Nagamune, and Takeo Yamaguchi
Organizer
The nth International Symposium on Cytochrome P450 Biodiversity and Biotechnology
Place of Presentation
the Museum of Natural Sciences, Turin, ITALY
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