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Elucidation of neural mechanisms underlying modification of instinct behavior by internal brain state changes by multi-scale analysis of the silkmoth brain

Research Project

Project/Area Number 24370031
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionThe University of Tokyo

Principal Investigator

KANZAKI Ryohei  東京大学, 先端科学技術研究センター, 教授 (40221907)

Co-Investigator(Renkei-kenkyūsha) KAZAWA Tomoki  東京大学, 先端科学技術研究センター, 特任研究員 (00507824)
SAKURAI Takeshi  東京大学, 先端科学技術研究センター, 特任講師 (20506761)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords神経行動 / 昆虫 / 脳 / 行動修飾
Outline of Final Research Achievements

To understand neural mechanisms underlying how internal brain state modulates animal behaviors, we focused on serotonergic modulation in pheromone processing system of the silkmoth Bombyx mori. We generated transgenic silkmoth lines that were designed to express a transgene under the upstream sequence of a tryptophan hydroxylase gene that encodes an enzyme involved in serotonin biosynthesis. One of the lines labeled serotonergic neurons innervating the lateral accessory lobe, a premotor center for pheromone-source searching behavior. For functional analysis of these neurons by optogenetic approaches, we established a light emission system to locally stimulate biological tissues.
We also found a previously unrecognized transformation of pheromone concentration information that indicates the antennal lobe encodes odorant concentration changes rather than absolute concentration in pulse trains of pheromone stimuli.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (31 results)

All 2015 2014 2013 2012 Other

All Journal Article (11 results) (of which Peer Reviewed: 10 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (16 results) (of which Invited: 11 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Odorant concentration differentiator for intermittent olfactory signals2014

    • Author(s)
      Fujiwara T, Kazawa T, Sakurai T, Fukushima R, Uchino K, Yamagata T, Namiki S, Haupt SS, Kanzaki R
    • Journal Title

      Journal of Neuroscience

      Volume: 34 Issue: 50 Pages: 16581-16593

    • DOI

      10.1523/jneurosci.2319-14.2014

    • NAID

      120006348495

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dynamic use of optic flow in pheromone tracking behaviour by male silkmoth, Bombyx mori.2014

    • Author(s)
      Pansopha P, Ando N, Kanzaki R
    • Journal Title

      Journal of Experimental Biology

      Volume: 217 Issue: 10 Pages: 1811-1820

    • DOI

      10.1242/jeb.090266

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Information flow through neural circuits for pheromone orientation in the moth2014

    • Author(s)
      Namiki S, Iwabuchi S, Pansopha Kono P, Kanzaki R
    • Journal Title

      Nature Communications

      Volume: 5 Issue: 1 Pages: 5919-5919

    • DOI

      10.1038/ncomms6919

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 昆虫の脳を理解し,脳をつくる2014

    • Author(s)
      神崎亮平
    • Journal Title

      化学工学

      Volume: 78 Pages: 387-390

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] カイコガの高選択・高感度な性フェロモン認識の分子・神経基盤2014

    • Author(s)
      櫻井健志、神崎亮平
    • Journal Title

      Sanshi-Konchu Biotec

      Volume: 83 Issue: 2 Pages: 2_115-2_127

    • DOI

      10.11416/konchubiotec.83.2_115

    • NAID

      130004705722

    • ISSN
      1881-0551, 1884-7943
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Giant vesicles functionally expressing membrane receptors for an insect pheromone.2014

    • Author(s)
      Hamada, S., M. Tabuchi, T. Toyota, T. Sakurai, T. Hosoi, T. Nomoto, K. Nakatani, M. Fujinami and R. Kanzaki
    • Journal Title

      Chemical Communications

      Volume: 50 Issue: 22 Pages: 2958-2961

    • DOI

      10.1039/c3cc48216b

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Postsynaptic Odorant Concentration Dependent Inhibition Controls Temporal Properties of Spike Responses of Projection Neurons in the Moth Antennal Lobe.2014

    • Author(s)
      Fujiwara T, Kazawa T, Haupt SS, Kanzaki R
    • Journal Title

      PLoS One

      Volume: 9 Issue: 2 Pages: e89132-e89132

    • DOI

      10.1371/journal.pone.0089132

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and neural mechanisms of sex pheromone reception and processing in the silkmoth Bombyx mori2014

    • Author(s)
      Sakurai T, Namiki S, Kanzaki R
    • Journal Title

      Frontiers in Physiology

      Volume: 5

    • DOI

      10.3389/fphys.2014.00125

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pheromone responsiveness threshold depends on temporal integration by antennal lobe projection neurons2013

    • Author(s)
      Tabuchi M, Sakurai T, Mitsuno H, Namiki S, Minegishi R, Shiotsuki T, Uchino K, Sezutsu H, Tamura T, Haupt SS, Nakatani K, Kanzaki R
    • Journal Title

      Proceedings of the National Academy of Sciences of USA

      Volume: 110(38) Issue: 38 Pages: 15455-60

    • DOI

      10.1073/pnas.1313707110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insect-Machine Hybrid System for Understanding and Evaluating the Sensory-Motor Control by Sex Pheromone in Bombyx mori2013

    • Author(s)
      Kanzaki R, Minegishi R, Namiki S, Ando N
    • Journal Title

      Journal of Comparative Physiology A

      Volume: 199 Issue: 11 Pages: 1037-1052

    • DOI

      10.1007/s00359-013-0832-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] カイコガにおける性フェロモンの特異的認識機構2013

    • Author(s)
      櫻井健志,田渕理史,神崎亮平
    • Journal Title

      日本味と匂学会誌

      Volume: 20 Pages: 41-47

    • Related Report
      2013 Annual Research Report
  • [Presentation] Neural Basis of Odor-Source Localization in the Silkmoth: from genes, neural networks, and behavior to robots2015

    • Author(s)
      Ryohei Kanzaki
    • Organizer
      Annual Talks 2015 - Biology Across Scales
    • Place of Presentation
      Bangalore, India
    • Year and Date
      2015-01-05 – 2015-01-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 昆虫科学が拓く生物エレクトロニクス2014

    • Author(s)
      神崎亮平
    • Organizer
      日経エレクトロニクスセミナー
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2014-10-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Analysis and synthesis of odor-source localization in insects: From genes, neural networks, and behavior to robots2014

    • Author(s)
      Ryohei Kanzaki
    • Organizer
      11th International Congress of Neuroethology / 36th Annual Meeting of the Japanese Society for Comparative Physiology and Biochemistry
    • Place of Presentation
      札幌コンベンションセンター、札幌
    • Year and Date
      2014-07-28 – 2014-08-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Visual processing pathways and their roles in modulation of pheromone-triggered behavior in the male silkmoth, Bombyx mori2014

    • Author(s)
      Poonsup Pansopha, Noriyasu Ando, Ryohei Kanzaki
    • Organizer
      11th International Congress of Neuroethology / 36th Annual Meeting of the Japanese Society for Comparative Physiology and Biochemistry
    • Place of Presentation
      札幌コンベンションセンター、札幌
    • Year and Date
      2014-07-28 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 昆虫科学から迫る次代のバイオミメティクス2014

    • Author(s)
      神崎亮平
    • Organizer
      科学工学技術委員会
    • Place of Presentation
      東京都中小企業振興公社、東京
    • Year and Date
      2014-06-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 昆虫の嗅覚機構を再現した匂いセンサ・匂い源探索ロボット2014

    • Author(s)
      神崎亮平
    • Organizer
      第42回センサ&アクチュエータ技術シンポジウム
    • Place of Presentation
      化学会館、東京
    • Year and Date
      2014-05-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 次代の技術を担う「昆虫力」~昆虫科学が迫る昆虫の感覚・脳・行動のしくみとその応用~2013

    • Author(s)
      神崎亮平
    • Organizer
      日本蚕糸学会第83会大会公開シンポジウム特別講演
    • Place of Presentation
      つくば農林ホール,茨城(招待講演)
    • Year and Date
      2013-03-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] 次代の技術を担う「昆虫力」~昆虫の感覚・脳・行動のしくみ~2013

    • Author(s)
      神崎亮平
    • Organizer
      JEITA技術委員会.講演会
    • Place of Presentation
      大手センタービル、東京(招待講演)
    • Year and Date
      2013-01-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] Insect-Machine Hybrid System - New Directions in Bionic Engineering2013

    • Author(s)
      Kanzaki R
    • Organizer
      The 4th International Conference on Bionic Engineering
    • Place of Presentation
      Nanjing, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Insect-Machine Hybrid System for Understanding and Evaluating the Sensory-Motor Control2013

    • Author(s)
      Kanzaki R, Minegishi R and Ando N
    • Organizer
      ThE20 Minisymposium "Remote Controlled Insect Biobots" 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Osaka International Conference Center, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 昆虫パワーの科学一昆虫からみた脳科学・ロボット・教育の未来2012

    • Author(s)
      神崎亮平
    • Organizer
      第29回浜松コンファレンス
    • Place of Presentation
      アクトシティ浜松中ホール、静岡(招待講演)
    • Year and Date
      2012-11-03
    • Related Report
      2012 Annual Research Report
  • [Presentation] Analysis and synthesis of odor source localization in the silkmoth.2012

    • Author(s)
      Kanzaki, Ryohei
    • Organizer
      International Symposium Olfaction in insects under debate
    • Place of Presentation
      Wurzburg, Germany(招待講演)
    • Year and Date
      2012-07-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] 次代の技術を担う「昆虫力」~昆虫の感覚・脳・行動のしくみ~

    • Author(s)
      神崎亮平
    • Organizer
      平成25年度JEITA「電子部品部会」講演会
    • Place of Presentation
      大手センタービルJEITA401-403会議室
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 次代の技術を担う「昆虫力」~昆虫の感覚・脳・行動のしくみ~

    • Author(s)
      神崎亮平
    • Organizer
      第104回 発明教室 未来技術セミナー(石川県発明協会)
    • Place of Presentation
      石川県地場産業振興センター
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 昆虫とロボットから探る脳科学

    • Author(s)
      神崎亮平
    • Organizer
      平成25 年度 複雑系生命システム研究センター研究会
    • Place of Presentation
      東京大学駒場I キャンパス
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 昆虫力を観る・知る・利用する-遺伝子・ニューロン・脳からロボットへ-

    • Author(s)
      神崎亮平
    • Organizer
      宇都宮大学VBL講演会
    • Place of Presentation
      宇都宮大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] サイボーグ昆虫、フェロモンを追う2014

    • Author(s)
      神崎亮平
    • Total Pages
      108
    • Publisher
      岩波書店
    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京大学先端科学技術研究センター 生命知能システム分野 神崎・高橋研究室

    • URL

      http://www.brain.rcast.u-tokyo.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京大学先端科学技術研究センター 生命知能システム分野 神崎・高橋研究室

    • URL

      http://www.brain.rcast.u-tokyo.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.brain.rcast.u-tokyo.ac.jp/

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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