| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
|---|
| Outline of Final Research Achievements |
To understand neural mechanisms underlying how internal brain state modulates animal behaviors, we focused on serotonergic modulation in pheromone processing system of the silkmoth Bombyx mori. We generated transgenic silkmoth lines that were designed to express a transgene under the upstream sequence of a tryptophan hydroxylase gene that encodes an enzyme involved in serotonin biosynthesis. One of the lines labeled serotonergic neurons innervating the lateral accessory lobe, a premotor center for pheromone-source searching behavior. For functional analysis of these neurons by optogenetic approaches, we established a light emission system to locally stimulate biological tissues.
We also found a previously unrecognized transformation of pheromone concentration information that indicates the antennal lobe encodes odorant concentration changes rather than absolute concentration in pulse trains of pheromone stimuli.
|
