Structure determination of histamine H1 receptor
| Project/Area Number |
24370044
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
SHIMAMURA Tatsuro 京都大学, 医学(系)研究科(研究院), 講師 (90391979)
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| Co-Investigator(Kenkyū-buntansha) |
HINO Tomoya 鳥取大学, 大学院工学研究科, 講師 (40373360)
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| Co-Investigator(Renkei-kenkyūsha) |
IWATA So 京都大学, 大学院医学研究科, 教授 (60452330)
ASADA Hidetsugu 京都大学, 大学院医学研究科, 研究員 (20399041)
OGASAWARA Satoshi 京都大学, 大学院医学研究科, 研究員 (30546685)
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| Research Collaborator |
LEURS Rob
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | アレルギー / 花粉症 / GPCR / 結晶構造解析 / ヒスタミン |
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| Outline of Final Research Achievements |
Antihistamines are inverse agonists of histamine H1 receptor and work well to relieve symptoms of allergies including pollen fever. Antihistamines are known to show undesirable side effects caused by the low receptor selectivity and the high ability to cross the blood-brain barrier. We succeeded to crystallize histamine H1 receptor in complex with the second-generation antihistamines. The structural information of these complexes would be useful for the development of new generation antihistamines without side effects.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Proteoliposome-based selection of a recombinant antibody fragment against the human M2 muscarinic acetylcholine receptor.2014
Author(s)
Suharni, Nomura Y, Arakawa T, Hino T, Abe H, Nakada-Nakura Y, Sato Y, Iwanari H, Shiroishi M, Asada H, Shimamura T, Murata T, Kobayashi T, Hamakubo T, Iwata S, Nomura N.
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Journal Title
Monoclon Antib Immunodiagn Immunother
Volume: 33
Issue: 6
Pages: 378-385
DOI
NAID
Related Report
Peer Reviewed
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