Crystallographic study of multidrug efflux proteins coupled with outer membrane channel TolC
| Project/Area Number |
24370045
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 異物排出トランスポーター / 立体構造 / 多剤耐性 / 蛋白質 / 細菌 / 抗生物質 / 感染症 |
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| Outline of Final Research Achievements |
Xenobiotic extruding pumps have recently been known to be widely distributed in living organisms from mammalian to bacteria as a host-defense mechanism in cellular level. These pumps confer multidrug resistance for cancer cells and pathogenic bacteria. We had reported the first inhibitor-bound structures of MexB which couples with TolC type outer membrane channel. Additionally, we succeeded in solving the crystal structure of new substrate binding MexB. These are result to lead to transporter-oriented structure based drug development.
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Report
(4 results)
Research Products
(43 results)
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[Presentation] 異物排出の構造的基盤2014
Author(s)
山口明人, 中島良介, 櫻井啓介
Organizer
生体エネルギー研究会 第40回討論会
Place of Presentation
愛媛
Year and Date
2014-12-11 – 2014-12-13
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