Elucidation of coordination between HP1 and polycomb complex for function of heterochromatin
| Project/Area Number |
24370071
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Hokkaido University |
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Principal Investigator |
OBUSE Chikashi 北海道大学, 先端生命科学研究科(研究院), 教授 (00273855)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | ヘテロクロマチン / HP1 / ポリコーム複合体 / G9a複合体 / HP 1 |
|---|
| Outline of Final Research Achievements |
Combining robust and flexible feature of heterochromatin is one of most important characteristics of "Epigenetics". To give the both features to heterochromatin, the relationships between constitutive heterochromatin based on H3K9me3-HP1 (heterochromatin protein 1) and facultative heterochromatin based on H3K27me3-PRC2 (polycomb repressive complex 2) will be responsible for the mechanism. This study revealed that HP1 associates with PRC2 through a histone H3K9 methyltransferase. These molecular links will contribute to understand the mechanism for robustness and flexibility of heterochromatin.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] An Annexin A1- FPR1 Interaction Contributes to Necroptosis of Keratinocytes in Severe Cutaneous Adverse Drug Reactions.2014
Author(s)
Saito N, Qiao H, Yanagi T, Shinkuma S, Nishimura K, Suto A, Fujita Y, Suzuki S, Nomura T, Nakamura H, Nagao K, Obuse C, Shimizu H, Abe R.
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Journal Title
Sci Transl Med.
Volume: 6
Pages: 245-295
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Genetically encoded system to track histone modifications in vivo2013
Author(s)
Yuko Sato, Masanori Mukai, Jun Ueda, Michiko Muraki, Timothy J. Stasevich, Naoki Horikoshi, Tomoya Kujirai, Hiroaki Kita, Taisuke Kimura, Seiji Hira, Yasushi Okada, Yoko Hayashi-Takanaka, Chikashi Obuse, Hitoshi Kurumizaka, Atsuo Kawahara, Kazuo Yamagata, Naohito Nozaki and Hiroshi Kimura
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Journal Title
Scientific Rep.
Volume: 3
Pages: 2436-2436
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Hi s tone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair.2013
Author(s)
Koichi Sato. Masamichi Ishiai, Kazue Toda, Satoshi Furukoshi, Akihisa Osakabe, Hiroaki Tachiwana, Yoshimasa Takizawa, Wataru Kagawa, Hiroyuki Kitao, Naoshi Dohmae, Chikashi Obuse, Hiroshi Kimura, Minoru Takata, Hitoshi Kurumizaka
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Journal Title
EMBO Journal
Volume: 31
Pages: 3524-2536
DOI
Related Report
Peer Reviewed
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