| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
We addressed the regulatory mechanism of chromosomal stability, and following findings were obtained. 1) A novel molecule CAMP functions as a complex with HP1, REV7, and POGZ. CAMP knockout mice die soon after birth. 2) A nuclear pore complex component Nup188 recruits NuMA to spindle poles for chromosome segregation. 3) A microtubule associated factor CLIP-170 regulates chromosome segregation through the mechanisms such as Plk1 recruitment to kinetochores. 4) Two motor molecules, Kid and CENP-E, function for chromosome alignment on the spindle.
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