| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
|---|
| Outline of Final Research Achievements |
In this study, first we identified the consensus sequence of the novel phosphorylation motif (non-S/TP motif) of Cdk1 and clarified the relationship between Cdk1 phosphorylations of the non-S/TP motif and the classical S/TP motif. Furthermore, we showed the binding of multiple M phase kinases to the S/TP motif and also the mode of the bindings. Moreover, we demonstrated the concerted regulation of the M phase by binding of the multiple M phase kinases to the S/TP motif. Thus, our study showed the molecular basis of the mechanism by which Cdk1 functions as the master M phase kinase.
|
