| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Outline of Final Research Achievements |
As observed as severe muscular atrophy of astronauts in micro-gravity situation, a loss of mechanical stimuli causes failure of homeostasis maintenance. However, molecular mechanisms by which cells and tissues sense physical force stimuli are largely unknown. In this research, we have identified several force-sensitive factors that control gene expression in living tissues. By extensive analyses, we now know that these factors play essential roles in cardiac development, maintenance of circulatory homeostasis, energy metabolism wound healing/regeneration. Our data provide fundamental insights into the disuse syndrome of astronauts and bedridden old patients, obesity/diabetes and their therapeutic approaches.
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