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Molecular mechanisms of neuronal identity acquisition in olfactory sensory neurons

Research Project

Project/Area Number 24370087
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Developmental biology
Research InstitutionUniversity of Fukui (2013-2014)
The University of Tokyo (2012)

Principal Investigator

TAKEUCHI Haruki  福井大学, 医学部, 客員准教授 (70548859)

Research Collaborator NAKASHIMA Ai  福井大学, 医学部, 学術研究員 (60706331)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords神経科学 / 神経回路 / 嗅覚 / 発生 / 軸索ガイダンス / 感覚情報 / 脳科学 / 嗅覚受容体 / 発生学 / 軸索投射 / 神経活動
Outline of Final Research Achievements

In the mouse olfactory system, olfactory sensory neurons (OSNs) expressing the same olfactory receptor (OR) converge their axons to a specific set of glomeruli in the olfactory bulb. It has been demonstrated that ORs control transcriptional levels of axon guidance and sorting molecules to regulate axonal projection of OSNs. However, it remains unknown what is the signaling source for activating ORs. In the present study, we found that ligand-independent basal activities induced by expressed ORs play important roles in the targeting of OSN axons. This finding provides compelling evidence that the basal activity, which had been considered to be noise, is physiologically-important.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (7 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] 嗅覚情報処理を担う神経地図形成の分子基盤2014

    • Author(s)
      竹内春樹
    • Journal Title

      生体の科学

      Volume: 65 Pages: 516-517

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Neural map formation in the mouse olfactory system2014

    • Author(s)
      Takeuchi, H. and Sakano, H.
    • Journal Title

      Cell. Mol. Life Sci.

      Volume: 1 Issue: 16 Pages: 1-9

    • DOI

      10.1007/s00018-014-1597-0

    • NAID

      130007718437

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons2013

    • Author(s)
      Nakashima A., Takeuchi H., Imai T., Saito H., Kiyonari H., Abe T., Chen A., Weinstein L.S., Yu C.R., Storm D.R., Nishizumi H., and Sakano H
    • Journal Title

      Cell

      Volume: 154 Issue: 6 Pages: 1314-1325

    • DOI

      10.1016/j.cell.2013.08.033

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible roles of robo1+ ensheathing cells in guiding dorsal-zone olfactory sensory neurons in mouse2013

    • Author(s)
      ※Aoki M, ※Takeuchi H, Nakashima A, Nishizumi H and Sakano H
    • Journal Title

      Developmental Neurobiology

      Volume: 73 Pages: 828840-828840

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Olfactory receptor and neural pathway responsible for highly selective sensing of musk odor.2013

    • Author(s)
      Shirasu, M., Yoshikawa, K., Takai, Y., Nakashima, A., Takeuchi, H., Sakano, H., and Touhara, K.
    • Journal Title

      Neuron

      Volume: 81 Issue: 1 Pages: 165-178

    • DOI

      10.1016/j.neuron.2013.10.021

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 嗅覚神経地図形成の分子基盤2015

    • Author(s)
      竹内春樹
    • Organizer
      生命動態の分子メカニズムと数理
    • Place of Presentation
      京都大学稲盛ホール
    • Year and Date
      2015-03-16 – 2015-03-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 神経スパイク列の再構成から迫る活動依存的な回路形成機構の解明2014

    • Author(s)
      竹内春樹、中嶋藍、坂野仁
    • Organizer
      CREST領域会議、数理デザイン道場
    • Place of Presentation
      OIST
    • Year and Date
      2014-10-28 – 2014-10-29
    • Related Report
      2014 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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