• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular mechanisms for micropeptide functions

Research Project

Project/Area Number 24370090
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Developmental biology
Research InstitutionKobe University

Principal Investigator

KAGEYAMA Yuji  神戸大学, 遺伝子実験センター, 准教授 (90335480)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywordsマイクロペプチド / ショウジョウバエ / スクリーニング / 遺伝学 / 上皮細胞 / 形態形成 / 分子遺伝学 / 発生生物学 / 細胞増殖 / キイロショウジョウバエ / 短鎖ペプチド / 器官形成
Outline of Final Research Achievements

Eukaryotic gemomes contain a proportional numer of "micropeptide" genes that encode small peptides in extremely short ORFs. Micropeptides are distinguished from canonical active peptide molecules, which are translated as a long precursor and secreted into extracellular spaces, and should therefore function in cytoplasm, although little is known about its molecular mechanisms.
In this study, we focused on Drosophila polished rice gene that encode 11- and 32-aa micropeptides. We found that pri is specifically expressed in metamorphic stages and induced by ectopic application of ecdysone. Phenotypic analysis of hypomophic allies of the pri gene demonstrated that pri is essential for progress of metamorphosis and regulate ecdysone-dependent gene network.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (12 results)

All 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (9 results) (of which Invited: 1 results)

  • [Journal Article] Pri peptides are mediators of ecdysone for the temporal control of development2014

    • Author(s)
      H. Chanut-Delalande, Y. Hashimoto, A. Pelissier-Monier, R. Spokony, A. Dib, T. Kondo, J. Bohere, K. Niimi, Y. Latapie, S. Inagaki, L. Dubois, P. Valenti, C. Polesello, S. Kobayashi, B. Moussian, K. White, S. Plaza, Y. Kageyama, and F. Payre
    • Journal Title

      Nature Cell Biol.

      Volume: 16 Issue: 11 Pages: 1035-1044

    • DOI

      10.1038/ncb3052

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear lncRNAs as epigenetic regulators-beyond skepticism.2014

    • Author(s)
      Nakagawa, S., Kageyama, Y.
    • Journal Title

      Biochim. Biophys. Acta.

      Volume: 1839 Issue: 3 Pages: 215-222

    • DOI

      10.1016/j.bbagrm.2013.10.009

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The binding of multiple nuclear receptors to a single regulatory region is important for the proper expression of EDG84A in Drosophila melanogaster.2013

    • Author(s)
      Kazutaka Akagi, Kageyama, Y., Kayashima, Y., Takakura, Y., Hirose, S. and Ueda, H.
    • Journal Title

      J. Mol. Biol.

      Volume: 425 Issue: 1 Pages: 71-81

    • DOI

      10.1016/j.jmb.2012.10.020

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 長鎖ノンコーディングRNA の神経系における機能:ショウジョウバエlobe-less 変異体の細胞学的解析2014

    • Author(s)
      中村奈月、稲垣幸、影山裕二
    • Organizer
      日本RNA学会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-07-23 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Lobe-less RNAはポリコーム複合体と相互作用し、ショウジョウバエにおけるキノコ体の形態形成を制御している2014

    • Author(s)
      稲垣幸、佐藤昌直、中村奈月、小林悟、影山裕二
    • Organizer
      日本RNA学会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-07-23 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Lobe-less RNA is essential for mushroom body morphogenesis in Drosophila.2014

    • Author(s)
      Sachi Inagaki, Masanao Sato, Tomoyuki Miyashita, Natsuki Nakamura, Satoru Kobayashi and Yuji Kageyama
    • Organizer
      55th Annual Drosophila Research Conference
    • Place of Presentation
      San Diego (USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Lobe-less RNA is essential for mushroom body morphogenesis in Drosophila.2013

    • Author(s)
      Sachi Inagaki, Natsuki Nakamura, Masanao Sato, Satoru Kobayashi and Yuji Kageyama
    • Organizer
      第46回日本発生生物学会年会
    • Place of Presentation
      松江
    • Related Report
      2013 Annual Research Report
  • [Presentation] MRE32/Lobe-less RNA is essential for mushroom body morphogenesis in Drosophila.2013

    • Author(s)
      稲垣幸、佐藤昌直、中村奈月、小林悟、影山裕二
    • Organizer
      第15回日本RNA学会年会
    • Place of Presentation
      松山
    • Related Report
      2013 Annual Research Report
  • [Presentation] Drosophila Lobe-less RNA is essential for axon guidance in development of mushroom body neurons.2013

    • Author(s)
      Sachi Inagaki, Natsuki Nakamura, Masanao Sato, Satoru Kobayashi and Yuji Kageyama
    • Organizer
      2013 Riboclub Annual Meeting
    • Place of Presentation
      Orford (Canada)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Lobe-less RNA はショウジョウバエキノコ体の形態形成を介して学習・記憶を制御している2013

    • Author(s)
      稲垣幸、佐藤昌直、宮下知之、中村 奈月、小林悟、斉藤実、影山裕二
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] ショウジョウバエ成虫脳の形態形成と記憶・学習を制御する長鎖ノンコーディングRNA2013

    • Author(s)
      影山裕二、稲垣幸
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Physiological roles of MRE32 RNA in Drosophila optic lobe and wing development.2012

    • Author(s)
      Sachi Inagaki, Masanao Sato, Yasuo Fukami, Yuji Kageyama
    • Organizer
      第14回日本RNA学会年会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi