| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
Eukaryotic gemomes contain a proportional numer of "micropeptide" genes that encode small peptides in extremely short ORFs. Micropeptides are distinguished from canonical active peptide molecules, which are translated as a long precursor and secreted into extracellular spaces, and should therefore function in cytoplasm, although little is known about its molecular mechanisms.
In this study, we focused on Drosophila polished rice gene that encode 11- and 32-aa micropeptides. We found that pri is specifically expressed in metamorphic stages and induced by ectopic application of ecdysone. Phenotypic analysis of hypomophic allies of the pri gene demonstrated that pri is essential for progress of metamorphosis and regulate ecdysone-dependent gene network.
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