| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Outline of Final Research Achievements |
Animals often show left-right (LR) asymmetry in their body structures. In some vertebrates, the mechanisms underlying LR symmetry breaking and the subsequent signals responsible for LR asymmetric development are well understood. However, in invertebrates, the molecular bases of these processes are largely unknown. Therefore, we have been studying the genetic pathway of LR asymmetric development in Drosophila. We especially focused on the embryonic gut that is the first organ developing directional LR asymmetry.
In this study, we attempted to understand LR symmetry breaking process in Drosophila. We found that the Wnt signaling is required for LR asymmetric development of the embryonic gut before its LR asymmetric morphogenesis. We also found that the early stage of LR asymmetric development of the embryonic gut depend on the function of genetic pathway involving extra macrochaetae-daughterless cascade.
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