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Evolution of the immunoproteasome PSMB8 gene

Research Project

Project/Area Number 24370094
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Evolutionary biology
Research InstitutionThe University of Tokyo

Principal Investigator

NONAKA MASARU  東京大学, 理学(系)研究科(研究院), 教授 (40115259)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords進化 / 平衡選択 / プロテアソーム / 二型性 / 主要組織適合性抗原複合体 / MHC / 免疫プロテアソーム / 遺伝子進化
Outline of Final Research Achievements

The proteasome subunit beta type 8 gene (PSMB8) encodes one of the beta subunits of the immunoproteasome responsible for the generation of peptides presented MHC class I molecules. Phylogenetic analysis revealed the presence of dichotomous ancient lineages persisting more than 400 million years. To clarify the whole picture of evolution of the PSMB8 dimorphism, more than 10 species of teleost, amphibian and reptile were analyzed. Most of them seem to have lost one of the two lineages, and then have recovered dimorphism within the other lineage. However, this explanation is incompatible with the presence of a strong selective pressure to keep dimorphism, and interallelic sequence homogenization was proposed as a possible evolutionary mechanism for the apparent recurrent regeneration of PSMB8 dimorphism in these animals. An extremely strong balancing selection acting on PSMB8 dimorphism was implicated in an unprecedented pattern of allele evolution.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (19 results)

All 2015 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 2 results,  Open Access: 2 results) Presentation (8 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] Evolution of the complement system in protostomes revealed by de novo transcriptome analysis of six species of Arthropoda2015

    • Author(s)
      Reo Sekiguchi, Masaru Nonaka
    • Journal Title

      Developmental and Comparative Immunology

      Volume: 50 Issue: 1 Pages: 58-67

    • DOI

      10.1016/j.dci.2014.12.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evolution of dimorphisms of the proteasome subunit beta type 8 gene (PSMB8) in basal ray-finned fish2014

    • Author(s)
      Noro M, Nonaka M
    • Journal Title

      Immunogenetics

      Volume: 66 Issue: 5 Pages: 325-334

    • DOI

      10.1007/s00251-014-0767-4

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Epididymal C4b-binding protein is processed and degraded during transit through the duct and is not essential for fertility2014

    • Author(s)
      MI Nonaka, E Zsigmond, A Kudo, H Kawakami, K Yoshida, N Kawano, K Miyado, M Nonaka, RA Wetsel
    • Journal Title

      Immunobiology

      Volume: 220 Issue: 4 Pages: 467-475

    • DOI

      10.1016/j.imbio.2014.11.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dimorphisms of the proteasome subunit beta type 8 gene (PSMB8) of ectothermic tetrapods originated in multiple independent evolutionary events2013

    • Author(s)
      Huang, C. H., Tanaka, Y., Fujito, N. T., & Nonaka, M.
    • Journal Title

      Immunogenetics

      Volume: 65 Issue: 11 Pages: 811-821

    • DOI

      10.1007/s00251-013-0729-2

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel third complement component C3 gene of Ciona intestinalis expressed in the endoderm at the early developmental stages2013

    • Author(s)
      Hibino, T. & Nonaka, M.
    • Journal Title

      Invertebrate Survival Journal

      Volume: 10 Pages: 29-37

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly divergent dimorphic alleles of the proteasome subunit beta type-8 (PSMB8) gene of the bichir Polypterus senegalus : implication for evolution of the PSMB8 gene of jawed vertebrates2012

    • Author(s)
      Fujito NT, Nonaka M
    • Journal Title

      Immunogenetics

      Volume: (in press) Issue: 6 Pages: 447-453

    • DOI

      10.1007/s00251-012-0602-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-lived dichotomous lineages of the proteasome subunit beta type 8 (PSMB8) gene surviving more than 500 million years as alleles or paralogs2012

    • Author(s)
      Tsukamoto, K. , Fujito, N. T. , Yoshizaki, G. , & Nonaka, M.
    • Journal Title

      Mol. Biol. Evol.

      Volume: 29 Pages: 3071-3079

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A population genetic study on the relationship between medaka fish and wet-rice-cultivation spreads over the Japanese archipelago2012

    • Author(s)
      Katsumura, T., Oda, T., Tsukamoto, K., Sekiya, Y., Yamashita, T., Aso, M.,
    • Journal Title

      Anthropol. Sci.

      Volume: 120 Pages: 81-89

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guideline for Hereditary Angioedema (HAE) 2010 by the Japanese Association for Complement Research - Secondary Publication2012

    • Author(s)
      Horiuchi T, Ohi H, Ohsawa I, Fujita T,Matsushita M, Okada N, Seya T,Yamamoto T, Endo Y, Hatanaka M,Wakamiya N, Mizuno M, Nakao M, OkadaH, Tsukamoto H, Matsumoto M, Inoue N,Nonaka M, Kinoshita T.
    • Journal Title

      Allergology International

      Volume: 61 Issue: 4 Pages: 559-562

    • DOI

      10.2332/allergolint.12-RAI-0471

    • NAID

      130004873058

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 節足動物における補体系の進化2014

    • Author(s)
      関口 玲生、野中 勝
    • Organizer
      第51回 補体シンポジウム
    • Place of Presentation
      神戸常磐大学
    • Year and Date
      2014-08-22 – 2014-08-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] MHCとプロテアソームPSMB8遺伝子の二型性の進化2013

    • Author(s)
      野中 勝
    • Organizer
      日本比較免疫学会第25回学術集会
    • Place of Presentation
      岡山理科大学、岡山
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 条鰭類における免疫プロテアソームサブユニットPSMB8遺伝子の二型性の進化2013

    • Author(s)
      野呂 恵、野中 勝
    • Organizer
      日本比較免疫学会第25回学術集会
    • Place of Presentation
      岡山理科大学、岡山
    • Related Report
      2013 Annual Research Report
  • [Presentation] フグ目におけるPSMB8遺伝子の二型性の進化2012

    • Author(s)
      源島裕祐
    • Organizer
      日本進化学会第14回東京大会
    • Place of Presentation
      首都大学東京(東京)
    • Year and Date
      2012-08-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] Long-term trans-species dimorphism of the PSMB8 gene in the actinopterygian MHC region2012

    • Author(s)
      藤戸尚子
    • Organizer
      The 12th international congress of International Society of Developmental an(i Comparative Immunology
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Recurrent revival of dimorphism of the PSMB8 gene during tetrapod evolution2012

    • Author(s)
      Ching-Huei Huang
    • Organizer
      The 12th international congress of International Society of Developmental and Comparative Immunology
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 鱗移植片の急性拒絶反応に関わるメダカMHC遺伝子の同定2012

    • Author(s)
      坂内英美
    • Organizer
      第21回日本組織適合性学会大会
    • Place of Presentation
      明治大学駿河台キャンパス(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The evolution of The Proteasome Subunit Beta Type 8 (PSMB8) Gene in Non-eutherian Mammals2012

    • Author(s)
      Ming-Hsuan Yu
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡(福岡)
    • Related Report
      2012 Annual Research Report
  • [Book] MACPF/CDC Proteins-Agents of Defence, Attack and Invasion2014

    • Author(s)
      Nonaka M
    • Total Pages
      329
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] Complement System : Evolution (Encyclopedia of Life Science)2013

    • Author(s)
      Nonaka, M. & Sekiguchi, R.
    • Publisher
      John Wiley & Sons Ltd
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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