Evolution of the immunoproteasome PSMB8 gene
| Project/Area Number |
24370094
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Evolutionary biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NONAKA MASARU 東京大学, 理学(系)研究科(研究院), 教授 (40115259)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 進化 / 平衡選択 / プロテアソーム / 二型性 / 主要組織適合性抗原複合体 / MHC / 免疫プロテアソーム / 遺伝子進化 |
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| Outline of Final Research Achievements |
The proteasome subunit beta type 8 gene (PSMB8) encodes one of the beta subunits of the immunoproteasome responsible for the generation of peptides presented MHC class I molecules. Phylogenetic analysis revealed the presence of dichotomous ancient lineages persisting more than 400 million years. To clarify the whole picture of evolution of the PSMB8 dimorphism, more than 10 species of teleost, amphibian and reptile were analyzed. Most of them seem to have lost one of the two lineages, and then have recovered dimorphism within the other lineage. However, this explanation is incompatible with the presence of a strong selective pressure to keep dimorphism, and interallelic sequence homogenization was proposed as a possible evolutionary mechanism for the apparent recurrent regeneration of PSMB8 dimorphism in these animals. An extremely strong balancing selection acting on PSMB8 dimorphism was implicated in an unprecedented pattern of allele evolution.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] A population genetic study on the relationship between medaka fish and wet-rice-cultivation spreads over the Japanese archipelago2012
Author(s)
Katsumura, T., Oda, T., Tsukamoto, K., Sekiya, Y., Yamashita, T., Aso, M.,
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Journal Title
Anthropol. Sci.
Volume: 120
Pages: 81-89
Related Report
Peer Reviewed
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[Journal Article] Guideline for Hereditary Angioedema (HAE) 2010 by the Japanese Association for Complement Research - Secondary Publication2012
Author(s)
Horiuchi T, Ohi H, Ohsawa I, Fujita T,Matsushita M, Okada N, Seya T,Yamamoto T, Endo Y, Hatanaka M,Wakamiya N, Mizuno M, Nakao M, OkadaH, Tsukamoto H, Matsumoto M, Inoue N,Nonaka M, Kinoshita T.
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Journal Title
Allergology International
Volume: 61
Issue: 4
Pages: 559-562
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed
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