| Project/Area Number |
24370102
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied anthropology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA SHINGO 独立行政法人国立精神, 神経医療研究センター・精神保健研究所, 室長 (80570291)
HIDA AKIKO 独立行政法人国立精神, 神経医療研究センター・精神保健研究所, 室長 (20333354)
TSUJIMURA SEI-ICHI 鹿児島大学, 理工学研究科, 准教授 (10381154)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | 生理人類学 / 環境適応 / 光環境 / 光感受性 / 遺伝的多型 / メラノプシン / 瞳孔 / 光 / 波長 / 遺伝子多型 / 概日リズム / 睡眠 / 色光 / 遺伝子 / 一塩基多型 / 適応 |
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| Outline of Final Research Achievements |
In our previous study, we found that a single nucleotide polymorphism of I394T (rs1079610) in the melanopsin gene was associated with pupillary light response in human. Since melanopsin has a characteristic spectral sensitivity to light, in this study, we aimed to determine associations among I394T genotypes and physiological responses under diverse light wavelengths. In the results, the CC+CT subjects showed greater percentage of pupillary constriction than the TT subjects under light conditions that strongly excites melanopsin (high-intensity and short wavelength). In addition, there was a difference in spectral sensitivity between the genotype groups; the TC subjects and TT subjects showed peak responsiveness at 476 nm light and 480 nm light, respectively. In the comparison of habitual sleep between the genotype groups, sleep/wake timing of CC subjects was significantly later than the TT or TC subjects.
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