| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
We analyzed the molecular mechanism by which Cucumber mosaic virus (CMV) induces necrosis on inoculated leaves of Arabidopsis. We could show direct evidence of the protein-protein interaction between the 2b protein of CMV (2b) and host catalase (Cat3). The stability of the 2b-Cat3 complex seems to be regulated by cellular proteasome; the more stable the complex is, the more rapidly it is degraded. For the host plant, Cat3 may function as an anti-CMV factor that can interfere with the function of 2b.
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