| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
In this study, we analyzed the suppression mechanism of DNA viral propagation in response to DNA viral infection using a silkworm cell line and silkworm nucleopolyhedroviruses (BmNPV). We found that two predicted membrane proteins, tetraspanin and integrin, both of which genes are up-regulated in response to BmNPV infection, were involved in suppression of BmNPV propagation in the cells. We further demonstrated that tetraspanin regulated BmEts-dependent repression of expression of the viral immediate early gene. We believe that these findings contribute to elucidation of the mechanisms of insect immunity against DNA viruses.
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