| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
Four major mechanisms have been found to effects host virulence after infection by RSL1: (1) twitching motility and associated virulence were affected in the host cells,(2) among 12 RSL1 genes enhanced during prolonged infection, orf105, orf106, and orf121 worked for growth activation but orf137 and orf209 strongly inhibited the growth, (3) RSL1 induced RSS prophages in the host cells, and (4) phage resistance working in the host was associated with LPS structure and function, so that resistant cells all lost virulence because of LPS deficiency.
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