| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
|
|---|
| Outline of Final Research Achievements |
Structures of novel bacteriocins from lactic acid bacteria, such as enterocin NKR-5-3 and enterocin F4-9, were analyzed and determined. Biosynthetic gene clusters of leaderless bacteriocins such as lacticin Q and lacticin Z, and circular bacteriocins such as leucocyclicin Q were analyzed, and the genes responsible for their secretion and self-immunity were identified. Antibacterial action of lacticin Q was found to involve pore formation on cell membrane of target cells as well as accumulation and scavenging ability of hydroxyl radicals in target cells.
|
