Elucidation of the molecular mechanisms of biosynthesis and action of novel bacteriocins from lactic acid bacteria and their applications
| Project/Area Number |
24380051
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Kyushu University |
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Principal Investigator |
ZENDO Takeshi 九州大学, (連合)農学研究科(研究院), 助教 (50380556)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | バクテリオシン / 抗菌ペプチド / 乳酸菌 / 細菌 / 応用微生物 |
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| Outline of Final Research Achievements |
Structures of novel bacteriocins from lactic acid bacteria, such as enterocin NKR-5-3 and enterocin F4-9, were analyzed and determined. Biosynthetic gene clusters of leaderless bacteriocins such as lacticin Q and lacticin Z, and circular bacteriocins such as leucocyclicin Q were analyzed, and the genes responsible for their secretion and self-immunity were identified. Antibacterial action of lacticin Q was found to involve pore formation on cell membrane of target cells as well as accumulation and scavenging ability of hydroxyl radicals in target cells.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Gene cluster responsible for secretion of and immunity to multiple bacteriocins, the NKR-5-3 enterocins2014
Author(s)
Ishibashi N, Himeno K, Masuda Y, Perez RH, Iwatani S, Zendo T, Wilaipun P, Leelawatcharamas V, Nakayama J, Sonomoto K
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Journal Title
Appl Environ Microbiol
Volume: 80
Issue: 21
Pages: 6647-6655
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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