| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Outline of Final Research Achievements |
Synthesis of peptide molecules of was tried by a combination of fragment synthetic technology with precise control of selective disulfide-bond formation. The reaction was performed in a reverse micellar reaction field.
As a result, the new synthesis method was established for combining several peptides fragments between the aimed positions of each molecule. The peptide-chain elongation was also achieved by introducing the hydrophobic tag on each peptide fragment by using the reverse micellar reaction field. After peptide skeletons were formed, the hydrophobic tags and other deprotection reactions were performed to give key units of insulin molecu
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