| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|
|---|
| Outline of Final Research Achievements |
Occurrence of progesterone was found to spread widely in the plant kingdom ranging from higher plants to lower plants including mosses and ferns. Furthermore some species of microorganisms were found to produce progesterone. Deuterated pregnenolone and progesterone were synthesized to clarify the synthesis and metabolism of progesterone. Using these deuterated steroids, it was found that pregnenolone is converted to progesterone which, in turn, is further metabolized to 5a-dihydrproesterone、allopregnanolone and epiallopregnanolone. It seems that the maize gene TS2 is involved in the synthesis of progesterone. It was also found that jasmonic acid influences the synthesis of progesterone. In addition, tobacco flowers have higher ability to convert pregnenolone to progesterone than leaves.
|
