| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Outline of Final Research Achievements |
Immunomodulatory function of probiotics and its enhancement with food factors were investigated. When carnosine, a dipeptide contained abundantly in meat and fish meat, was orally administered to mice, intestinal IgA production was enhanced only in the presence of gut microbiota. Oral administration of live Lactococcus lactis C59 cells enhanced the induction of oral tolerance. The enhancing effect was up-regulated when narigenin, a flavonoid with a regulatory T cell enhancing activity, was orally administered with the probiotic C59. In vitro analyses using murine lymphocytes newly identified flavonoids which enhance the differentiation and/or activity of regulatory T cells or regulatory B cells.
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