Analysis of immunomodulatory function of probiotics and its enhancement with food factors
| Project/Area Number |
24380065
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TOTSUKA Mamoru 東京大学, 農学生命科学研究科, 准教授 (70227601)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 乳酸菌 / 制御性Ｔ細胞 / IgA抗体 / フィトケミカル / カルノシン / 制御性B細胞 / 経口免疫寛容 / 莢膜多糖 / 制御性T細胞 / IgA抗体産生 / 腸管上皮細胞 / インフルエンザウイルス / T細胞 / IgA / ダイゼイン |
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| Outline of Final Research Achievements |
Immunomodulatory function of probiotics and its enhancement with food factors were investigated. When carnosine, a dipeptide contained abundantly in meat and fish meat, was orally administered to mice, intestinal IgA production was enhanced only in the presence of gut microbiota. Oral administration of live Lactococcus lactis C59 cells enhanced the induction of oral tolerance. The enhancing effect was up-regulated when narigenin, a flavonoid with a regulatory T cell enhancing activity, was orally administered with the probiotic C59. In vitro analyses using murine lymphocytes newly identified flavonoids which enhance the differentiation and/or activity of regulatory T cells or regulatory B cells.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Effects of Enteric-coated Lactoferrin Tablets Containing <i>Lactobacillus brevis</i> subsp. <i>coagulans</i> on Fecal Properties, Defecation Frequency and Intestinal Microbiota of Japanese Women with a Tendency for Constipation: a Randomized Placebo-controlled Crossover Study2013
Author(s)
Noriyuki Suzuki, Michiaki Murakoshi, Tomoji Ono, Satoru Morishita, Min Jung Bae, Mamoru Totsuka, Makoto Shimizu, Keikichi Sugiyama, Hoyoku Nishino and Norio Iida
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Journal Title
Bioscience of Microbiota, Food and Health
Volume: 32
Issue: 1
Pages: 13-21
DOI
NAID
ISSN
2186-3342
Related Report
Peer Reviewed
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