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Epigenomic and integrated omics analyses on the mechanism by which fetal nutrition induces life style-related diseases

Research Project

Project/Area Number 24380066
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Food science
Research InstitutionThe University of Tokyo

Principal Investigator

KATO Hisanori  東京大学, 総括プロジェクト機構, 教授 (40211164)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywordsタンパク質栄養 / エピジェネティクス / 高血圧 / 胎児期 / メチル化 / マイクロアレイ / メチローム
Outline of Final Research Achievements

Malnutrition during pregnancy is known to increase the risk of life style-related diseases of the offspring after their maturation. We have previously revealed the effect of dietary low protein during pregnancy (maternal protein restriction, MPR), on gene expression in pups of SHRSP, a hypertensive rat model, after growth. In the present study, we exhaustively investigated the effects of the MPR on gene expression in the kidney of SHRSP, just before and after birth and found that many genes relating to extracellular matrix and apoptosis were affected. Such changes in gene expression have been attributed to so-called “epigenetic” modulations, which include changes in DNA methylation. Then we extensively analyzed the alterations in DNA methylation by using next generation sequencing technology in the kidney of MPR rats. Around twenty CpG islands were found to be differentially methylated, which involved the coding region of the prostaglandin E2 receptor gene.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (7 results)

All 2015 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Adverse effects of excessive leucine intake depend on dietary protein intake: A transcriptomic analysis to identify useful biomarkers.2013

    • Author(s)
      Imamura, W., Yoshimura, R., Takai, M., Yamamura, J., Kanamoto, R. and Kato, H.
    • Journal Title

      J. Nutr. Sci. Vitaminol.

      Volume: 59 Pages: 45-55

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] タンパク質栄養に起因する生活習慣病発症機序 胎児期から新生児期に刻まれる栄養の記憶2013

    • Author(s)
      大谷りら、村上哲男、加藤久典
    • Journal Title

      化学と生物

      Volume: 51 Pages: 785-788

    • NAID

      130004707385

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Role of the renin-angiotensin-aldosterone system in the enhancement of salt sensitivity caused by prenatal protein restriction in stroke-prone spontaneously hypertensive rats2012

    • Author(s)
      Otani, L., Sugimoto, N., Kaji, M., Murai, M., Chang, S.-J., Kato, H. and Murakami, T
    • Journal Title

      J. Nutr. Biochem

      Volume: (印刷中) Issue: 8 Pages: 892-899

    • DOI

      10.1016/j.jnutbio.2011.04.014

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] タンパク質およびアミノ酸栄養に起因する生活習慣病発症機序の解明2012

    • Author(s)
      大谷りら、佐藤正幸、小山彩香、村上哲男 加藤久典
    • Journal Title

      アミノ酸研究

      Volume: 6 Pages: 141-147

    • Related Report
      2012 Annual Research Report
  • [Presentation] Genome-wide methylation analysis of transgenerational effects of maternal protein2015

    • Author(s)
      Lila N Otani, Masayuki Sato, Kenji Saito, Fumihito Miura, Katsuhiko Shirahige, Takashi Ito, Hisanori Kato
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胎児期低タンパク質暴露による高血圧のエピジェネティクス2012

    • Author(s)
      加藤久典
    • Organizer
      日本アミノ酸学会第6回学術大会
    • Place of Presentation
      千葉大学(千葉県)(招待講演)
    • Year and Date
      2012-09-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] 胎児期タンパク質制限が血圧調節関連遺伝子の制御におよぼす影響2012

    • Author(s)
      佐藤正幸、今門泰久、大谷りら、加藤久典
    • Organizer
      日本DOHaD研究会年会
    • Place of Presentation
      国立保健医療科学院(埼玉県)
    • Year and Date
      2012-08-04
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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