Effect of dietary beta-glucan on the resistibility of intestinal epithelia to intestinal viruses and its mechanisms
| Project/Area Number |
24380069
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OSHIMA Kenzi 名古屋大学, 生命農学研究科, 助教 (90391888)
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| Co-Investigator(Renkei-kenkyūsha) |
KATAYAMA Kazuhiko (60342903)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | βグルカン / 腸上皮細胞 / マクロファージ / 腸管ウイルス / 食物繊維 |
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| Outline of Final Research Achievements |
β-Glucan is a polysaccharide contained as a cell wall component of plant, algae, fungi, yeast, etc. It is a glucose-polymer classified into a dietary fiber because of its indigestibility. Possible absorption of dietary β-glucan and activation of intestinal immune system by the absorbed β-glucan were investigated using cell culture systems mimicking intestinal epithelia and viruses as well as virus-like particles (VLPs). β-Glucan taken up by phagocytes was degraded and released, and the released β-glucan activated neighboring cells, resulting in the release of various humoral factors. The β-glucan taken up and degraded by phagocytes was suggested to affect the resistibility of intestinal epithelia to intestinal viruses.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Prevalence of Helicobacter pylori infection by birth year and geographic area in Japan.2014
Author(s)
Ueda J, Gosho M, Inui Y, Matsuda T, Sakakibara M, Mabe K, Nakajima S, Shimoyama T, Yasuda M, Kawai T, Murakami K, Kamada T, Mizuno M, Kikuchi S, Lin Y, Kato M.
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Journal Title
Helicobacter
Volume: 19(2)
Issue: 2
Pages: 105-110
DOI
Related Report
Peer Reviewed
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