| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
β-Glucan is a polysaccharide contained as a cell wall component of plant, algae, fungi, yeast, etc. It is a glucose-polymer classified into a dietary fiber because of its indigestibility. Possible absorption of dietary β-glucan and activation of intestinal immune system by the absorbed β-glucan were investigated using cell culture systems mimicking intestinal epithelia and viruses as well as virus-like particles (VLPs). β-Glucan taken up by phagocytes was degraded and released, and the released β-glucan activated neighboring cells, resulting in the release of various humoral factors. The β-glucan taken up and degraded by phagocytes was suggested to affect the resistibility of intestinal epithelia to intestinal viruses.
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